1. Prof. Dr. Nenad Filipovic 1,2 1) Faculty of Mechanical Engineering, University of Kragujevac, Kragujevac, Serbia 2) Harvard School of Public Health, Boston, USA VIPSI - 2009 Conference – Belgrade COMPUTATIONAL BIOENGINEERING - Future predictive medicine?

2. Bioengineering is a broad field of scientific, biological, medical and engineering disciplines in which living systems, processes and materials are investigated together with nonliving subjects, environment and materials, in order to advance fundamental knowledge and improve life Subject and scope of bioengineering A schematic view of an integrated bioengineering science

3. Advanced simulations can predict the rupture of the aneurysm for specific patients Input data imported from standard DICOM images Revolutionary tool for cardiovascular surgical prediction and intervention Developing simulation technologies to characterize the effect of flow in plaque formation, the wall shear stress and the viscoelastic behavior of deformable walls, to predict stress and strain distribution within the blood vessel tissue in the active and passive conditions Simulating Blood Flow Through Arteries Predictive cardiovascular medicine

4. General display One-half of the radial cross-section Von Mises stress distribution Simulating Cartilage Mechanics Spinal motions segment - intervertebral disc, intradiscal pressure Mechanical response of a lumbar motion segment in axial torque combined with compression Complex spinal loads during dynamic lifting tasks

5. Thrombosis Modeling Nanoparticles Drug Delivery Thrombosis modeling Nanoparticles drug delivery in microvascular blood flow Pharmaceutical industry Drug delivery simulation Cancer research Thrombosis