1. Biomimetic Surfaces for Manipulation and Targeting Of Bacteria and / or Mammalian Cells (in Flow) Santore, santore@mail.pse.umass.edu Cell surface collector Polymer brush Adhesion element  Non-biological adhesion elements Robust, low cost  Highly selective multivalent binding of targets  Coupling of surface chemistry effects and flow  Re-usable, non-protein fouling, (implantable?) Maria Santore Polymer Science and Engineering Umass Amherst

2. Translational Potential Protein separationsEnrich / Discriminate Cancer Cells Selective Bacterial Killing? Mammalian Cell Reprogramming? Capture Stem Cells from Blood Bacteria Discrimination Harvest Auto-Immune Tcells

3. Opportunities for Collaboration Direct dynamic delivery to cells Protein separations development-ready Particular challenges for cell capture or bacterial discrimination Blood, breastmilk, other fluids…