1. Attitudes in diagnostics and approach of gastric cancer premalignant lesions Investigation Protocol Turma 16 Porto, 2008/2009 Prof. Dr. Altimiro da Costa Pereira

2. INTRODUCTION OBJECTIVES INVESTIGATION DESIGN POPULATION AND SAMPLE DATA COLLECTION Attitudes in diagnostics and approach of gastric cancer premalignant lesions REFERENCES

3. Gastric cancer Worldwide incidence High mortality and morbidity Geographical location Origin associated with premalignan t lesions Lack of practice methods Attitudes in diagnostics and approach of gastric cancer premalignant lesions OBJECTIVES INVESTIGATION DESIGN POPULATION AND SAMPLE DATA COLLECTION REFERENCES

4. Which are the foremost options of treatment and diagnostics of gastric cancer premalignant injuries being taken in Europe? Attitudes in diagnostics and approach of gastric cancer premalignant lesions INTRODUCTION INVESTIGATION DESIGN POPULATION AND SAMPLE DATA COLLECTION REFERENCES

5. Identification of attitudes and options regarding diagnostics, monitoring and treatment. Standardization of different European practices, concerning diagnostics and treatment, and creation of guidelines compiled in an European Practice Protocol. Attitudes in diagnostics and approach of gastric cancer premalignant lesions INTRODUCTION INVESTIGATION DESIGN POPULATION AND SAMPLE DATA COLLECTION REFERENCES

6. INTRODUCTION OBJECTIVES POPULATION AND SAMPLE DATA COLLECTION REFERENCES Study Design Metanalysis European centres survey Webpage Questionnair es European Practice Protocol Attitudes in diagnostics and approach of gastric cancer premalignant lesions

7. Gastroenterology European Centres Target population Target population Random sample of several Gastroenterology European Centres from European countries. (Group Random Sample) Sample Sample Attitudes in diagnostics and approach of gastric cancer premalignant lesions INTRODUCTION OBJECTIVES INVESTIGATION DESIGN DATA COLLECTION REFERENCES

8. Mixed questioner Attitudes in diagnostics and approach of gastric cancer premalignant lesions INTRODUCTION OBJECTIVES INVESTIGATION DESIGN POPULATION AND SAMPLE REFERENCES

9. Yoshio Yamaoka; Mototsugu Kato and Masahiro Asaka, Geographic Differences in Gastric Cancer Incidence Can be Explained by Differences between Helicobacter pylori Strains. Intern. Med. 47: 1077- 1083, 2008 M Dinis-Ribeiro, A Costa-Pereira, C Lopes, L Moreira-Dias. Guidelines for surveillance of patients with atrophic chronic gastritis and intestinal metaplasia in stomach would be welcome! Helicobacter Witold Bartnik. Clinical aspects of Helicobacter pylori infection. Pol Arch Med Wewn, 2008; 118 (7-8): 426-430 A. C. de Vries, J. Haringsma and E. J. Kuipers. The Detection, Surveillance and Treatment of Premalignant Gastric Lesions Related to Helicobacter pylori Infection Bowles MJ, Benjamin IS. ABC of the upper gastrointestinal tract. Cancer of the stomach and pancreas. BMJ 2001;323:1413–6 Sugiyama T, Asaka M. Helicobacter pylori infection and gastric cancer. Med Electron Microsc. 2004 Sep;37(3):149-57. Attitudes in diagnostics and approach of gastric cancer premalignant lesions INTRODUCTION OBJECTIVES INVESTIGATION DESIGN POPULATION AND SAMPLE DATA COLLECTION