1. No more broken hearts Presented by: Jeffrey Avila Janae Gonzales Burt Matthews Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJ Arterioscler. Thromb. Vasc. Biol. 2004;24;161-166 Naoki Ishimori et.al.

2. QTL What is it?

3. QTL What is it? What does it tell us?

4. QTL What is it? What does it tell us? Why is it important?

6. Overview of study B6X129

7. Overview of study B6X129 294 F2 Progeny Females

8. Overview of study B6X129 294 F2 Progeny Females High Fat Diet

9. Overview of study B6X129 294 F2 Progeny Females High Fat Diet Identify regions on chromosomes using QTL analysis

10. Phenotypic Measurements Plasma HDLAortic Lesions Micenmg/dlum B610 41±2 951±459 129x10 106±40 F18 84±30 F2294 81±1 228±44

11. QTL Analysis

14. Relevance 6 loci HDL + 5 Loci atherosclerosis suseptability identified The Future Lipoproteins Medications

15. Ways to increase my HDL levels Exercise Increase intake of Omega 3 fatty acids Eat Onions

16. A special thanks to…. Randy Von Smith Tobias Beckwith Dr. Brook Milligan NMSU RISE Program