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Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects)

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1 Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects)

2 Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects)

3 OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.

4 OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.

5 OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.

6 OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.

7 TNF α IL-6 Angiotensin Vasoconstriction ↓ NO Adiponectin ↓ Fibrinolysis PAI-1 Insulin Resistance Insulin Resistance Resistin Inflammation Insulin Resistance

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11 NUTRITION IN OBESITY Caloric Intake Percent Fat

12 OBESITY Oscai et al J Lipid Research 13:588-592, 1972. Sedentary Free Eaters Sedentary Pair Weighted Exercise Calories per Day

13 OBESITY Percent Fat (%) Body Weight (g)

14 OBESITY Fat Cell Size Fat Cell Number

15 Wilmore JH, Research Quarterly for Exercise and Sport 54:415- 425, 1983. Changes in Lean & Fat Mass with Training - Men

16 Wilmore JH, Research Quarterly for Exercise and Sport 54:415- 425, 1983. Changes in Lean & Fat Mass with Training - Women

17 Total weight, fat mass & lean mass changes with diet and exercise Miller, WC et al International Journal of Obesity 21:941-947, 1997

18 Lea n Fat Zuti & Golding, Physician & SportsMedicine 4:49-55, 1978 Weight Change (lbs) Lean vs. Fat Mass Loss with Diet & Exercise

19 Lea n Fat Franklin, B., et al. Research Quarterly 1976. Weight Change (lbs) Lean vs. Fat Mass Loss In Overweight Adults

20 Jakicic, et al. JAMA 282:1554-1560, 1999 SHORT vs. LONG BOUTS OF EXERICSE

21 Jakicic, et al. JAMA 282:1554-1560, 1999 ADHERENCE Minutes per week

22 Jakicic, et al. JAMA 282:1554-1560, 1999 Weight Loss

23 Lifestyle Activity vs. Exercise is Weight Loss Dunn, A.L. et al JAMA 281:327-334, 1999

24 MORBID OBESITY Reduce body fat in obese: Hill JO et al Physical Activity, Fitness, and Health: International Proceedings and Consensus statement, p 684-694, 1994. No Wt Loss Trend Wt Loss

25 Fogelholm, et al. Arch Int Medicine 160:2177-2184, 2000 PHYSICAL ACTIVITY & WEIGHT MAINTENANCE

26 Walden et al, Am J Clin Nutr 47:229-234, 1988. N= 20 upper N= 20 lower N= 20 upper N= 20 lower LOWER: Lost Abd & Glut LOWER: Lost Abd & Glut UPPER: Lost more on WHR Lost only from Abd Lost more weight UPPER: Lost more on WHR Lost only from Abd Lost more weight

27 Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects)

28 Tremblay, A., Int J Obesity 8:641-648, 1984. EXERCISE & THE FAT CELL

29 Lee, C.D., et al. American Journal of Clinical Nutrition 69:373-380, 1999 Fitness & Fatness

30 EXERCISE & NUTRITION Percent Body Fat (%) Pitts, et al Am J Physiol 246:R495, 1984

31 EXERCISE & METABOLIC RATE Poehlman, E.T., Med Sci Sports Exerc 21:515-525, 1989

32 EXERCISE & FOOD INTAKE Neiman, D.C., J A, Dietetic Assoc 90: 1557-1562, 1990

33 Postprandial Lipemia and Exercise Aldred, H.E, et al Metabolism 43:836-841, 1994

34 Baseline 1 year * * * * * * *

35 Baseline 1 year * interaction

36 Baseline 1 year

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