1. AP Biology (An Introduction) Mr. Boswell Room 208

2. Slide 2 of 34 Overview – 1 st Day 1. Attendance + Customary Introduction (10 min.) 3. Introduction to 21 st century science (45 min.) 4. Introduction to AP Biology (25 min.) 5. Introduction to Mr. Boswell (5 min.)

3. Slide 3 of 34 CUSTOMARY INTRODUCTION TO COLLEGE BIOLOGY

4. Slide 4 of 34 INTRODUCTION TO 21 ST CENTURY SCIENCE

5. Slide 5 of 34 20 th CENTURY SCIENCE

6. Slide 6 of 34 20 th Century Science  E. Schrödinger – Quantum Mechanics / Wave function  M. Planck – Quantum theory / Black Body Radiation  M. Curie – Radioactivity / Curium (# 96)  W. Heisenberg – Uncertainty Principle / NA  N. Bohr – Manhattan Project / Atomic Model of Protium  A. Einstein – Special Relativity / E = mc 2

7. Slide 7 of 34 Molecular Biology  Watson & Crick (1953)  Rosalind Franklin  M. Wilkins, & R. Gosling

8. Slide 8 of 34 Alba – GFP bunny  Expired in 2002  “Transgenic art”  AP Lab #6

9. Slide 9 of 34 Supermouse

10. Slide 10 of 34 Polygamy  Polygamous voles (rodents) can be genetically modified to behave monogamously  Some human males have the identical genetic marker as the polygamous voles  Guess what they have a difficult time doing?  Why did the researchers not identify the polygamous gene marker in women?

11. Slide 11 of 34 2 Quick Questions (rhetorical, of course) 1. Should we genetically modify males that have the polygamous genetic marker? 2. There are genetic markers for intelligence. If you could, would you genetically modify yourself for increased intelligence?

12. Slide 12 of 34 Human Genome Project  Completed in 2003  Joint Genome Institute (Walnut Creek, CA)  Sequenced entire human genome (DNA)  Cost $2.7 billion  2004, Celera (J. Craig Venter) = $300,000,000 (11%)  2010, Illumina (San Diego, CA) = $14,500 (0.0005%)  2013, $1,000 or less (estimate)

13. Slide 13 of 34 21 st Century Therapies  Gleevec – Chronic Myelogenous Leukemia  1 pill a day  Sprycel & Tasigna  BrCa-1 and BrCa-2 gene tests for breast and ovarian cancer  In 2010, Oncept DNA Vaccine  Canine Oral Melanoma  Transdermal application  June 2010, “siRNA ‘Cure’ for Ebola?” (Geisbert et al.)  May 20, 2010, first “synthetic” life form is created

14. Slide 14 of 34  “We are now part of an early radical biological revolution that will dwarf the industrial revolution.” -- Julian Savulescu (Oxford University)

15. Slide 15 of 34 Futurama  Juan Enriquez  TED Talks (www.ted.com)www.ted.com  http://www.ted.com/talks/juan_enriquez_shares_mindboggling_new_science.html http://www.ted.com/talks/juan_enriquez_shares_mindboggling_new_science.html  Cell Generation  Tissue Generation  Robots  Homo Evolutis

16. Slide 16 of 34 INTRODUCTION TO AP BIOLOGY

17. Slide 17 of 34 Exit Interview Comments  “…take the class only if you enjoy biology or the sciences.”  “If he/she doesn’t wish to go into the field of science, I’d highly dissuade them from taking the course.”  “If a student is only taking a course to have it on her transcript then she will have a horrible time.”  “…you must learn a ton of information in a short period of time.”

18. Slide 18 of 34 Page 2  “AP Biology is nothing like honors Biology.”  “…the teacher should have removed students from the class who were not up to the standards of the course.”  “Some people played on the computer or did not pay attention in class. Why are they still here?”

19. Slide 19 of 34 2009 AP Biology Results  Pass Rate = 74%  “5”s = 37%  Students = 43

20. Slide 20 of 34 Why this class is difficult… 1. Biology knowledge base is deficient  How many years ago did you take Honors Biology? 2. Honors Biology ≠ AP Biology 3. 55 Chapters (1,230 pages) 4. 3 credits vs. 8 credits

21. Slide 21 of 34 Why this class not difficult… 1. Clear expectations  Vocabulary & Objectives 2. Information is readily available 3. Course Materials sourced from 3 Biology textbooks 4. Course materials are easily accessible 5. Few complicated concepts

22. Slide 22 of 34 What is a College Level Course?  Student-Driven Learning  Role of teacher is to highlight some important points  Will NOT cover every concept in class  “students are expected to work independently outside the class”

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27. Slide 27 of 34 Announced Assignments

28. Slide 28 of 34 Class Discussions  You WILL be called on to attempt an answer  I want to hear what you have to say  Make all questions and comments relevant to the content discussion  If your question is off topic, write it down and ask it later

29. Slide 29 of 34 INTRODUCTION TO MR. BOSWELL

30. Slide 30 of 34 Background  Undergrad: Philosophy & Biochemistry  Masters: Medical Economics & Epidemiology  HHMI (Howard Hughes Medical Institute) Cohort  Inaugural Fellow (2008) @ University of Florida  AP Summer Institute (2007, 2008, & 2009)  Nova SE, BCPS, and Stanford University  AP Annual Conference (2008) in Seattle, WA  Lemelson-MIT InvenTeams sponsor

31. Slide 31 of 34 Workload  Faculty Sponsor – National Science Bowl  Simple Solutions for Helping Haiti (SSHH)  Genomics Sequencing Project???

32. Slide 32 of 34 Assignments  Diagnostic Test due by 2:00 am Tonight !!!  Biology: Diagnostic Test – (45 minutes)  http://www.quia.com/quiz/2493749.html http://www.quia.com/quiz/2493749.html  Student Sheet  http://www.quia.com/sv/425812.html http://www.quia.com/sv/425812.html  Any questions on the Student Sheet, email me @ bb@ap- bio.combb@ap- bio.com  Due by 2:00 am Tonight !!

33. Slide 33 of 34 Assignment (Page 2)  http://www.ap-bio.com http://www.ap-bio.com  Student Handbook: Printout, Read, & then Sign  Due Wednesday 8/25  Statement of Understanding (Page 4)  Lab Safety Contract (Page 5)  Academic Integrity (Honor Code) (Page 6)  AP Exam Exception (Page 7)  Homework / Summer Project  Chapters 1-3 - Due in class Wednesday 8/25  Chapters 4-5 - Due in class Friday 8/27

34. Slide 34 of 34 Assignment (Page 3)  Setup http://www.phschool.com accounthttp://www.phschool.com  Bring in Labeled CD (optional)  If you have not gotten ___ emails from Mr. Boswell, make sure you add name to email list  Review Basic Info – Chapter 1-3 for tomorrow