1. USF – Bioinformatics Master Project Outline Buck Institute The Mooney Lab Project Description 1

2. Buck Institute for Research on Aging History 1975 1986 1987 1989 1996 1987 – the Marin Superior Court selected the Institute to receive 15% of the net income from Beryl Buck’s estate 1989 – the Buck purchased a 488-acre parcel of undeveloped land on Mt. Burdell in Novato 1996 – construction began 1986 – The “Buck Institute on Aging” was incorporated. The San Francisco Foundation established. (at the time estimated at $11 - $12 million) 1999 2010 2010 – the value of the Buck Trust had grown to over $700 million, generating an annual income for the Institute of approximately $6 million per year. 1999 – The buck opened

3. Buck Institute for Research on Aging The Future for the Buck 3 New construction for stem-cell lab building - $41 million project

4. Buck Institute for Research on Aging The Buck Today 4 Mission – To increase the healthy years of life by investigating how normal aging contributes to the development of diseases. Employees – 200 Faculty – 18 labs

5. Buck Institute for Research on Aging o Parkinson disease o Alzheimer o cancer o stroke o nutrition o stress o genetics o stem cells o bioinformatics 5 Main research focus:

6. The Mooney Lab Responsibilities Core – support other labs in the institute to: o handle, store, and retrieve data o analyze biological data o use tools to generate biological hypotheses Independent research – o identify and classify diseases causing mutations o analyze protein structure to estimate structure similarities, predict catalytic and protein-protein interaction sites. o using ontologies to classify gene function 6

7. 7 Lab’s Web Tools Plugin - a container for a group of related resources (software components), embedded in a larger software application to extend its functionality. ChimeraPymol LSW Plugin LSW Plugin Life Science Web Services Plug-ins

8. Integration 8 p53 Cancer Mutations Lab’s Web Tools: S-Blest CRP MutDB PPI Chimera, Pymol: Analyze molecular structure Provide: images, animations, interactive Visualization setuptools SOAP API Easy Install Egg files Packages LSW Services: MD5 distutils Life Science Web Services Plug-ins services WSDL

9. 9 Contact info: tronnenoron@buckinstitute.org USF – Bioinformatics Master Project