1. Immunology Stack Slackers Facts by Mike Ori

2. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.

3. SLE antibodies

4. Anti-phospholipid Anti-smith Anti-dsDNA

5. SLE mortality factors

6. Short term: active disease (renal) and infection Long term: chronic renal failure, heart failure, malignancies, infection

7. SLE treatment

8. Immune suppression with cyclophosphamide and corticosteroids

9. Rheumatoid arthritis antibodies

10. RF

11. What is Rheumatoid Factor?

12. IgM antibodies directed against an immunoglobin such as IgG

13. RA description

14. Autoimmune attack on synovium leads to synovial overgrowth (fronding) onto articular cartilage causing irreversible joint destruction and malformation.

15. Other RA affected areas

16. Nodules in soft tissue, inflammation of the eye, vasculitis.

17. RA Immune cell involvement

18. CD4+ T and B cell infiltrates into joins with lymphoid follicle formation

19. Sjogren syndrome antibodies

20. Anti-SS-A/Ro Anti-SS-B/La

21. Sjogren description

22. Autoimmune destruction of exocrine gland epithelium particularly that of the salivary and lacrimal glands. Formation of germinal centers is possible.

23. Sjogren cells

24. CD4+ cells. NOTE: Although ab are present, they do not appear to be the principle cause of the damage. (Robbins)

25. Sjogren’s linked disease

26. 40x increased risk of B cell lymphoma

27. Scleroderma Ab

28. Anti-scl 70 Anti-nucleolar

29. Systemic sclerosis (Sceroderma) description

30. Progressive fibrosis located throughout the body particularly the skin and to a lesser extent the GI tract, kidneys, heart, muscles, and lungs.

31. Scleroderma cells

32. CD4+ T cells activate fibroblasts through unknown mechanisms.

33. Systemic Vasculitis Antibodies

34. Anti-neutrophil cytoplasmic antigen (ANCA)

35. Systemic vasculitis description

36. Immune response that results in either the deposition of Ab/Ag complexes or the binding of Ab in situ to elements of the endothelium. This results in a range of diseases involving the vasculature including wegener granulomatosis and churg-strauss. The reaction may range from mild to fatal.

37. Systemic vasculitis causes

38. Drugs and viruses