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Terry F. Hayamizu Mouse Genome Informatics, The Jackson Laboratory M OUSE A NATOMY O NTOLOGIES AND GXD.

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Presentation on theme: "Terry F. Hayamizu Mouse Genome Informatics, The Jackson Laboratory M OUSE A NATOMY O NTOLOGIES AND GXD."— Presentation transcript:

1 Terry F. Hayamizu Mouse Genome Informatics, The Jackson Laboratory M OUSE A NATOMY O NTOLOGIES AND GXD

2 Gene Expression Database (GXD)

3 Currently, GXD includes: a comprehensive literature index for mouse gene expression, with a primary emphasis on endogenous expression during embryonic development, covering >14,000 genes studied in >18,500 primary references detailed experimental data for >12,700 mouse genes in >50,000 expression assays from ~5000 references, including data for >1,500 mouse mutants, as well as >200,000 images associated with expression data over 1 million gene expression results annotated to specific mouse anatomy terms

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5 Stage i Stage j S TV XY U stage- dependent DAGs stage- independent DAG EMAPA s x s xy tvu vu W w EMAP

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7 anatomy ontology for mouse development developed by EMAP anatomy ontology for the postnatal mouse developed by GXD

8 Represent develops-from relationships EMAP / EMAPA TS X TS Y “develops-from” relationships TS 28

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10 GENOTYPE PHENOTYPE GENETICS DISEASE MODELS GENE EXPRESSION

11 Anatomy Gene Expression Phenotype Biological Process Disease Pathological Process

12 Adult Mouse Anatomy Gene Expression Database Mammalian Phenotype ontology Pathbase Gene Ontology NCI Thesaurus

13 Pathological Process Biological Process Anatomy Gene Expression Biological Process Phenotype Disease Gene Expression Phenotype Pathological Process Disease Gene Expression Biological Process Phenotype Pathological Process Disease

14 Anatomical ontologies from other species

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17 Other Mouse Genome Informatics (MGI) resources Mammalian Phenotype Ontology (MP) Gene Ontology (GO) Cell Ontology (CO) Edinburgh Mouse Atlas Project (EMAP) Duncan Davidson Richard Baldock Jonathan Bard Matthew Kaufman Gene Expression Database (GXD) Martin Ringwald Janan Eppig Jim Kadin Joel Richardson Jacqueline Finger Ingeborg McCright Constance Smith Jingxia Xu Acknowledgements GXD is funded by NIH/NICHD grant HD033745


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