1. INHALATION EXPOSURE LABORATORY EUGENE APPLEBAUM COLLEGE OF PHARMACY AND HEALTH SCIENCES WAYNE STATE UNIVERSITY CONTACT INFORMATION: DEEPAK BHALLA, PH.D., PROFESSOR PHONE: 577-3980 EMAIL: AD6268@WAYNE.EDUAD6268@WAYNE.EDU VANITHA BHOOPALAN, M.S., RESEARCH ASSISTANT PHONE: 577-3914 EMAIL: DY8663@WAYNE.EDUDY8663@WAYNE.EDU

2. RESEARCH TOPICS  NANOPARTICLE TOXICITY  NANOPARTICLE INTERACTION WITH OTHER INHALED POLLUTANTS: IN VIVO & IN VITRO  DRUG DELIVERY:  VOLUME MAY BE A LIMITING FACTOR  ALTERNATIVE – INTRATRACHEAL APPLICATION  THERAPEUTIC VALUE OF ANTIBODY-CONJUGATED NANOPARTICLES

3. OZONE CONC. DASIBI HUMIDITY AIROZONE AIR HYGRO- METER SAMPLING MODULE HUMIDIFIER AIR DRYER PURAFIL ACTIVATED CHARCOAL PARTICLE FILTER FL O W M ET E R PARTICLE FILTER NOSE-ONLY CHAMBERS FILTER SYSTEM EXHAUST OXYGENOXYGEN FL O W M ET E R OZONIZER TEMPERATURE OZONE EXPOSURE

4. OZONE EXPOSURE SYSTEM (NOSE-ONLY)

5. CHAMBERS FOR NOSE-ONLY EXPOSURE TO OZONE

6. OZONE, HUMIDITY AND TEMPERATURE MONITORS

7. SMOKE EXPOSURE

8. WALTON’S SMOKE MACHINE

10. SMOKE IN MIXING CHAMBER (2 SEC. PUFF)

11. HEAVY SMOKE IN MIXING CHAMBER

12. CIGARETTE SMOKE WHOLE-BODY EXPOSURE CHAMBER

13. FILTERED CIGARETTE NON - FILTERED CIGARETTE

14. SCIREQ SMOKE MACHINE

15. COMPUTER CONTROLLED SMOKING

16. SMOKING REGIMEN 1) Two second standard puff 2) A period of high flow during which the smoke is pushed downstream towards the animals. 3) A period of high flow during which the smoke is cleared out prior to the next puff. (1)(2)(3) Room Air Smoke

17. CIGARETTE SMOKE CONDENSATE (24.9mg/ml; 5/26/2011)