1. Biomolecular and Cellular Engineering Microbes Enzymes Biomolecules Metabolic Engineering Biopolymer Antibody Nano-Devices, Sensors, Environmental, Biosynthetic and Biomedical Applications Synthetic Biology Protein Engineering Directed Evolution

2. Research Interest Biomolecular Tools

3. Artificial Cellulosomes 1.Found in anaerobic microbes 2.Hydrolyze cellulose up to 50-fold faster due to synergy 3. Interaction between dockerin to cohesin is species specific Bayer et al., 2006

4. Synthetic Yeast Consortia

5. Virus detection and drug discovery Influenza

6. In situ Monitoring of Virus Replication Using Molecular Beacons Nucleus Uncoating Translation RNA replication Fixation with para-formaldehyde and permeabilization Triton X-100

7. In vivo detection of Coxsackie B6 virus in BGMK cells PlasDIC (t = 0 min) PlasDIC (t = 18 hr) Cells infected with 10 3 PFU, M.O.I.≈ 0.5 (15 min to 18 hr) Yeh et al. PNAS, 17522-17525, 2008

8. Acknowledgement 9 Graduate Students and 1 Postdoc