1. Cytokines Slackers Facts by Mike Ori

2. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.

3. IL-1 Secretor

4. Macrophage

5. IL-1 effects

6. Pyrogenic Acute inflammatory signal

7. IL-2 Secretor

8. Activated T helpers

9. IL-2 effects

10. Growth of T helpers and cytotoxic T’s

11. IL-3 secretor

12. Activated T cells

13. IL-3 effects

14. Stem cell growth in marrow similar to GM-GSF

15. IL-4 Secretor

16. TH2 cells Mast cells

17. IL-4 effects

18. Growth of B cells Ig class switching

19. IL-5 Secretor

20. TH2 cells Mast cells

21. IL-5 Function

22. B cell differentiation IgA class switch (notes have IgG1) Eosinophil production and activation

23. IL-6 Secretor

24. T helpers and macrophages

25. Il-6 function

26. Stimulates acute phase reactants and Ig

27. IL-7 Secretor

28. Thymic and bone marrow stromal cells

29. IL-7 function

30. Survival signal for immature T and B cells

31. IL-8 secretor

32. Macrophages

33. IL-8 Function

34. Major neutrophil chemotactic factor

35. IL-10 Secretor

36. T reg NOTE: Table in notes is different. See Mechanisms of immunity 12.

37. IL-10 function

38. Inhibits activated T cells

39. IL-12 secretor

40. B cells and macrophages

41. IL-12 function

42. Activates TH1 cells and NK cells

43. IL-13 Secretor

44. TH2 cells

45. Il-13 Function

46. Stimulates allergic response

47. IFN-gamma Secretor

48. TH1 cells

49. IFN-gamma function

50. Activates macrophages

51. IFN-I Secretor

52. Dendritic cells

53. IFN-I effects

54. General antiviral effects Antiproliferative action for somatic cells Signal 3 for T Cells

55. CD3 cell

56. T cells

57. CD 4 cells

58. T helper (TH1, TH2, TH17)

59. CD28 cell

60. T Helper

61. CD40L cell

62. T Helper

63. CD8 cell

64. Cytotoxic T cells

65. CD19 cell

66. B cells

67. CD20 cells

68. B cells

69. CD 40 cells

70. APC’s B cells, dendritic cells, macrophages

71. MHC-II cells

72. APC cells

73. TNF Alpha Secretor

74. Macrophages

75. TNF alpha function

76. Proinflammatory cytokine Apoptosis signal (weak?)

77. GM-CSF secretor

78. Monocytes T cells

79. GM-CSF function

80. Stimulates the marrow to produce monocytes and granulocytes

81. FAS receptor cells

82. Most (all?) human cells

83. Fas ligand cells

84. CD8 Cytotoxic T cells

85. FAS function

86. Induces apoptosis in host cells when signaled by CD8 cells.

87. Signal 1 components

88. TCR interacts with MHC-II along with CD4

89. Signal 2 components

90. B7 molecule on APC interact with CD-28 on T cells.

91. Signal 3

92. IL-12, IFN-I