1. BIG Process Flow Annexure A1

2. Call for Proposals Opens Call for Proposals Closes BIG Partners assigned proposals to review Preliminary screening by BIG Partner BIG Partner requests reviewers to evaluate Proposal not eligible 1 Jan 1 July ~ 14 Feb ~14 August Application process Slide 1 of 4 Application process Slide 1 of 4 Basic eligibility Topics relevant to biotech/biomed POC project for tech vs. basic research Basic eligibility Topics relevant to biotech/biomed POC project for tech vs. basic research

3. Receipt of reviewers comments BIRAC screening BIRAC shortlists applicants for presentation to TEP in Delhi Proposal not eligible Proposal recommended to BIRAC 2 pos/ 2; 2 pos/3 Proposal recommended to BIRAC 2 pos/ 2; 2 pos/3 Proposal not eligible 2 neg/ 2 2 neg/ 3 Proposal not eligible 2 neg/ 2 2 neg/ 3 Application process Slide 2 of 4 Application process Slide 2 of 4 Novelty or unmet need Technical feasibility of idea; do- ability; any prelim indication that it might work Can the team deliver? Technical capability. Project mgmt experience Potential to create IP or existing IP; Estimate of FTO based on reviewer’s experience. Can the project achieve impt goals in 18 months and Rs 50 lakhs? Are budget and timelines realistic? Novelty or unmet need Technical feasibility of idea; do- ability; any prelim indication that it might work Can the team deliver? Technical capability. Project mgmt experience Potential to create IP or existing IP; Estimate of FTO based on reviewer’s experience. Can the project achieve impt goals in 18 months and Rs 50 lakhs? Are budget and timelines realistic? Does the topic fit within scope of BIG? Does BIRAC concur with reviewer’s comments? Some prior art search is reqd? Does the topic fit within scope of BIG? Does BIRAC concur with reviewer’s comments? Some prior art search is reqd? 1 April 1 Sept

4. Presentation in Delhi to TEP. Decision by ESC Due diligence by BIG Partner; site visit; detailed discussion BIG Partner provides due diligence report to BIRAC Proposal not eligible In principle approval decision by ESC Proposal not selected ~ 15 May ~ 15 Oct ~ 1 June ~1 Nov ~ 1 July ~1 Dec Delays possible here if applicant needs time to produce documents Application process Slide 3 of 4 Application process Slide 3 of 4 Novelty or unmet need Technical feasibility of idea Technical credibility of PI Proposal budget/timelines realistic Novelty or unmet need Technical feasibility of idea Technical credibility of PI Proposal budget/timelines realistic Company legal and financial documents Project milestones/budgets; quotes Commitment of incubator Adequacy of facility available Tech transfer agreement; scientific support contracts Company legal and financial documents Project milestones/budgets; quotes Commitment of incubator Adequacy of facility available Tech transfer agreement; scientific support contracts

5. BIRAC does final review Agreement signed between Grantee and BIG Partner First installment released by BIG Partner. BIG Project can begin. First installment released by BIG Partner. BIG Project can begin. BIRAC okays final terms and signing of agreement by BIG Partner Proposal not selected ~ 1 Aug ~ 1 Jan ~ 1 Sept ~1 Mar Application process Slide 4 of 4 Application process Slide 4 of 4 All scheme requirements met

6. Project Review and Monitoring

7. First installment Next installment released Monitoring Phase Slide 1 of 1 Monitoring Phase Slide 1 of 1 Milestone “N” (Targets met!) + Utilization certificate Milestone “N” (Targets met!) + Utilization certificate Final Milestone (Targets met!) + Utilization certificate Final Milestone (Targets met!) + Utilization certificate Last installment (~5%) (after end of project) Last installment (~5%) (after end of project) BIG Partner All capex projected was purchased; set-up and working; logs maintained; insurance taken; AMC Sufficient staff engaged formally in project; all hiring against formal contracts Proper accounts maintained Project mgmt and business mentoring if asked/required BIG Partner All capex projected was purchased; set-up and working; logs maintained; insurance taken; AMC Sufficient staff engaged formally in project; all hiring against formal contracts Proper accounts maintained Project mgmt and business mentoring if asked/required Project Reviewing Committee Whether milestones met? Consider requests for moving timelines or milestone targets? Provide inputs to BIRAC on changes requiring BIRAC decisions. Ex – any budget changes. Technical mentoring Project Reviewing Committee Whether milestones met? Consider requests for moving timelines or milestone targets? Provide inputs to BIRAC on changes requiring BIRAC decisions. Ex – any budget changes. Technical mentoring