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Published byDaniella Price Modified over 9 years ago
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… Rejection Transplantation Biology:
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Kidney rejection:
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Allograft rejection: specificity and memmory.
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Adoptive transfer of skin allograft rejection.
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MHC-matching: microcytotoxicity assay
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Microcytotoxicity test.
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Mixed Lymphocyte Reaction.
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Luminex Cross-matching Assay: Checks for the presence of pre-existing anti-HLA antibodies in recipient serum to assess the risk of hyperacute rejection.
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Organ Rejection: 1.Hyperacute (immediate) : hours Pre-existing antibodies. 2.Acute: (weeks) Cell-mediated – MHC-mismatch. 3.Chronic (months, years) minor histocompatibility antigens.
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Transplantation of blood: blood transfusion.
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Hyperacute rejection of kidney graft.
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Allo-antibodies and chronic rejection.
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Black: Azathioprine + corticosteroids Blue: Cyclosporin A + corticosteroids
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Fraternal twins cattle
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“Transfusion of a goat’s blood” (1892) Jules Andler (1865-1952).
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