1. SYSTEM INDIVIDUAL MONITORING OF FUNCTIONAL AND ADAPTIVE HUMAN RESERVES
Konstantin Apykhtin, Ph.D., M.D., Institute for Occupational Health of NAMS of Ukraine, Kyiv
Vladimir Petrukhin, Prof., Dr. ; Sabir Shaykhlislamov, Anton Danshin, AlexeyZapara, Moscow Institute of Physics and Technology, Department of Control and Applied Mathematics

2. According to the WHO Constitution, "Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity“ (1946).
Health is primarily a state of the organism, which is characterized by the relation of structure and function, as well as the ability of regulatory systems to maintain a constant internal environment (homeostasis). (Nikolay N. Zajko, Prof., Dr. Med., Soviet pathophysiologist, ).

3. The disease is a disruption of the normal functioning of the body when exposed to damaging agents, resulting in a decrease of its adaptive capabilities (Nikolay N. Zajko).
The disease is a dynamic state of an organism characterized by disruption of normal flow of life processes, resulting in reduced biological and social abilities of a person.

4. Health ?
Disease

5. Health
Prenosological
changes
Disease

6. The levels of the organization
Biorhythms, coherence phase processes
in time
Temporary
Neuro-humoral regulation.
The hormone-receptor and synaptic interaction.
Informational
ATP synthesis in mitochondria,
the reactions of glycolysis.
Energy
The functioning of the organs and systems of the body
Functional
Cell organelles, components, membranes, structural proteins, enzymes, DNA
Structural

7. The sequence of development of pathological process
Temporary level
Informational level
Energy level
Functional level
Structural level 1 2 3 4 5
The time of occurrence of violations

8. Prenosological approach
Proposed by Soviet scientists Roman M. Baevsky, Vasily V. Parin and other (1966).
Based on the analysis of subtle changes in the temporal organization of control actions of the nervous and endocrine systems on chronotropic function of the sinus node of the heart.
Assumes a three-level hierarchical model of heart rhythm control.

9. III. II. I. HRV Reaction time: 25 – 300 sec VLF 6 – 25 sec LF
Levels:
subcortical sympathetic ergotrop nerve centers
Reaction time:
Spectral domain:
III.
25 – 300 sec
VLF
baroreflex center of the medulla oblongata
6 – 25 sec LF
II.
truncus sympathicus I.
n.n. vagus
2.5 – 6 sec HF
sequence of P-P (or R-R)
HRV

10. Rhytmogramm (graph of R-R intervals)
ECG
R-R
Rhytmogramm (graph of R-R intervals)

11. Our body works according to the following rules:
Normally, when the workload or everyday activity demands do not exceed the capacity of CVS (e.g. rest or light intensity work), the heart is regulated predominantly by autonomic level.
When the workload becomes higher, the organism starts to involve baroreflex level of regulation.
When the workload becomes too high or external conditions become too severe, the organism starts to involve sympathetic ergotropic and humoral level.
So, the higher intensity of work or adaptation, the higher level of regulation is involved.
Each higher level of regulation inhibits activity of lower levels.
The state of stress is characterized by increased heart rate (HR), increased sympathetic tone of ANS, increased blood pressure.
State of relaxation is characterized by decrease of HR, increase of parasympathetic tone (synonym – vagal tone) of ANS.

12. Stress-index of Roman M. Baevsky
SI = AMo (%) / (2*Mo*Δ RR)
Amplitude of mode (AMo) N n
AMo (%) = n / N * 100% n
[Mo] = sec
[ВР] = sec RR
RR min
RR max
Rest : ≈
0,05 sec
Mode
(Mo)
Sleep : < 50
Stress :
Range (Δ RR)
Miocardial infarction :

13. RMSSD = Indexes of vagal tone HRV = 20*ln (RMSSD) Used in USA R-R(i)

14. CardioMood website

15. CardioMood project: the team

16. Bluetooth
Site
Bluetooth

17. System requirements and compatibility
Smartphone or tablet requirements:
OS: Android 4.3+
Bluetooth: 4.0 Low Energy
Heart rate sensor:
Bluetooth Smart (e.g. Polar H7)

18. HRV Expert for Android http://bit.do/hrv-expert

19. Recording screen History
During measurement, the user can see current recording duration, heart rate as well as heart rate graph of the last 60 seconds. If the duration limit is set, the percentage of completion is indicated by a progress bar.
All measurements are listed under the History tab. Beside name, date and duration, user can see average stress and HRV score (20 ln RMSSD calculated over the whole recording). User can rename, search or delete their records.
Recording screen
History

20. Report includes time and frequency domain parameters, histogram analysis and Poincare plot

21. All calculated values as well as raw data can be exported to a text file

22. User home page All data from smartphone is synchronized with website
Profound analysis of RR-intervals with HRV methods
Data export to Excel tables
User groups and roles (users and doctors accounts on home.cardiomood.com and doctor.cardiomood.com respectively)

23. HRV analysis Artifacts filtration Different analysis epochs
Analysis of selected area
Over 20 calculated HRV parameters
Data export and printing

24. Key features Flexible measurement duration limits Comprehensive report
Time-domain parameters (SDNN, RMSSD, pNN50, etc)
Frequency-domain parameters (VLF, LF, HF, etc)
Histogram analysis
Poincare plot analysis
Artifacts and ectopic beat elimination
Raw-data export
Remote real-time monitoring (Internet required)
Cloud synchronization

25. Evolution of the modes of transmission of emotions
carrier pigeons

26. Evolution of the modes of transmission of emotions
Telegraph

27. Evolution of the modes of transmission of emotions
cell phone
telephone

28. Evolution of the modes of transmission of emotions

29. Evolution of the modes of transmission of emotions
CardioMood

30. Thank you for attention!