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Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 RNA-Seq Identifies an Extensive Network of Conserved Neural- Enriched Exons Regulated by nSR100 △ PSI: displaying.

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Presentation on theme: "Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 RNA-Seq Identifies an Extensive Network of Conserved Neural- Enriched Exons Regulated by nSR100 △ PSI: displaying."— Presentation transcript:

1 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 RNA-Seq Identifies an Extensive Network of Conserved Neural- Enriched Exons Regulated by nSR100 △ PSI: displaying an absolute percent spliced in change doxycycline

2 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 RNA-Seq Identifies an Extensive Network of Conserved Neural- Enriched Exons Regulated by nSR100

3 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 UGC-Containing Motifs Are Enriched Adjacent to Target Exons and Are Directly Bound by nSR100 In Vivo

4 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 UGC-Containing Motifs Are Enriched Adjacent to Target Exons and Are Directly Bound by nSR100 In Vivo PAR-iCLIP IP

5 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Binds Directly Upstream of Suboptimal 30 Splice Sites to Promote Neural Exon Inclusion Polypyrimidine tract Branch point

6 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Binds Directly Upstream of Suboptimal 30 Splice Sites to Promote Neural Exon Inclusion Polypyrimidine tract

7 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Interaction Partners Are Enriched in Early-Acting Splicing Complex Proteins

8 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Interaction Partners Are Enriched in Early-Acting Splicing Complex Proteins  g/ml

9 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 Opposing Regulation of Neural Exons by PTBP1 and nSR100 Mouse cortex tissues development E,embryonic; P, postnatal

10 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 Opposing Regulation of Neural Exons by PTBP1 and nSR100 ESC: embryonic stem cells NESC: neuroepithelial stem cells Radial NP:radial neural progenitors DIV: days in vitro

11 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Directly Overcomes PTBP1-Mediated Repression to Promote Exon Inclusion

12 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Directly Overcomes PTBP1-Mediated Repression to Promote Exon Inclusion

13 Mol Cell.Mol Cell. 2014 Sep 9. pii: S1097-2765 nSR100 Directly Overcomes PTBP1-Mediated Repression to Promote Exon Inclusion 50,100,200 ng 100,200 ng 200 + 50,100,200 ng

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