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Chem 509 Signal Transduction Winter 2010 Lecture 4 Comparative genome hybridization, bisulfite modification and the vision system.

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Presentation on theme: "Chem 509 Signal Transduction Winter 2010 Lecture 4 Comparative genome hybridization, bisulfite modification and the vision system."— Presentation transcript:

1 Chem 509 Signal Transduction Winter 2010 Lecture 4 Comparative genome hybridization, bisulfite modification and the vision system

2 CGHA AKA Comparative Genome Hybridization Weiss et al., 1999

3 http://images.google.com/imgres?imgurl=http://atlasgeneticsoncology.org/Deep/Images/ComparCancCytogFig3.jpg&imgrefurl=http://atlasgeneticsoncology.org/Deep/ComparCancerCytogID 20011.html&usg=__KVryJjPbKCV4DZYcGMMGn_TrzcY=&h=522&w=425&sz=86&hl=en&start=4&itbs=1&tbnid=1nOIvE599_nmSM:&tbnh=131&tbnw=107&prev=/images%3Fq%3DC omparative%2BGenome%2BHybridizaton%2BWeiss%26hl%3D en%26sa%3DG%26gbv%3D2%26tbs%3Disch:1

4 Weiss et al., 1999

5 http://catalog.takara-bio.co.jp/IMAGES/ge001a.gif

6 http://en.wikipedia.org/wiki/Bisulfite_sequencing 3’AAATAGCAA 5’ATTTTATGG 3’AAATAACAA 5’ATTTTATGG

7 Proc Natl Acad Sci U S A. 1996 September 3; 93(18): 9821–9826. Boldface: Differences between modified primers and unmodified primers. Differences between methylated/modified and unmethylated/modified are underlined.

8 S. Ramón y CajalS. Ramón y Cajal, Structure of the Mammalian Retina, 1900Mammalian

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