1. Rashid A. Chotani, MD, MPH Adjunct Professor, GWU Chotani@gwu.edu

2. Highlights as of 14 January, 2014  Total Reported Cases = 21,296 [HCW: 825]  Total Reported Deaths = 8,429 [HCW: 493]  Overall CFR= ~40% [~60%]  Phase-3 trials of two candidate Ebola vaccines are set to begin at the end of January and early February in Liberia, Sierra Leone and Guinea  It will take about six months for results from the phase-3 trials to be known  The production of vaccines will go on while the trials are underway  Huge stock of millions of doses of vaccine available by mid-year  Highest number of cases in 45+ age group (slide # 5)slide # 5  Compared with children (people aged 14 years and under), people aged 15 to 44 are three times more likely to be affected (35 reported cases per 100,000 population, compared with 101 per 100,000 population)  People aged 45 and over (130 reported cases per 100,000 population) are almost 4 times more likely to be affected than are children  Case incidence  Low in Guinea  In the previous week, reported its lowest weekly total of new confirmed cases since the week ending 17 August 2014  Overall Proportion: 26 reported cases per 100,000 population  Low in Liberia  Case numbers remain low, with no confirmed cases nationally for the final 2 days of the week ending 11 January, and the lowest weekly total of confirmed cases since the first week of June 2014  Overall Proportion: 210 cases per 100,000 population  Decreasing in Sierra Leone  Decline in case incidence for the second week running, and recorded its lowest weekly total of new confirmed cases since the week ending 31 August 2014  Overall Proportion: 176 cases per 100,000 population Source: WHO/CDC/SOS International/ProMed

3. Overall Status as of 14 January, 2015 Senegal declared outbreak free: 17 October Nigeria declared outbreak free: 19 October Spain declared outbreak free: 02 December Mali 8 Cases & 6 Deaths Nigeria 20 Cases & 8 Deaths USA 4 Cases & 1 Death Senegal 1 Case 0 Death Spain 1 Case 0 Death UK/Scotland 1 Case 0 Death These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: WHO/CDC/SOS International

4. HCW Status as of 14 January 2015 Total Cases 825 Total Deaths 493 Case-Fatality Rate ~ 60% One death in USA was a HCW infected in Guinea Mali 2 Cases & 1 Deaths Nigeria 11 Cases & 5 Deaths USA 3 Cases & 1 Death Spain 1 Case 0 Death UK 1 Case 0 Death * The marked increase from the total of HCW infections reported last week is due to additional cases reported from Sierra Leone that have occurred since the onset of the epidemic. These are not infections that have occurred between the two most recent reporting periods. These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: WHO/CDC/SOS International For each country the first three bars represent cases & the subsequent three bars represent deaths NOT New Cases*

5. Country Cumulative Cases By Gender* (per 100,000 population) By Age Strata # (per 100,000 population) MaleFemale0-14 years15-44 years45+ years Guinea 1334 (25) 1430 (26) 442 (10) 1564 (34) 736 (47) Liberia 2538 (128) 2444 (124) 831 (48) 2653 (155) 1015 (190) Sierra Leone 4125 (145) 4423 (153) 1771 (73) 4821 (186) 1936 (262) Total 7997 (78) 8297 (81) 3044 (35) 9038 (101) 3687 (130) Cumulative number of confirmed and probable cases by Gender and Age Strata in Guinea, Liberia, and Sierra Leone Population figures are based on estimates from the United Nations Department of Economic and Social Affairs. *Excludes cases for which data is not available on gender. # Excludes cases for which data on age are not available. These numbers are subject to change due to ongoing reclassification, retrospective investigation and availability of laboratory results. Source: UNDESA/WHO