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Cytosolic [Ca] RyR2 open probability ECC gain Ca transient contractility DADs - SCD [Ca] Time Iso CHF
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IP3RRyR Skel muscle++++ Smooth m.++++ Neurons+++ IP3ActivatesNone RyanodineNoneLocks open/closes Caffeine (5 mM)InhibitsActivates Ca 2+ IP3R1 - biphasic IP3R2/3 - opens biphasic RRNoneinhibits Heparininhibitsactivates
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Excitation-secretion coupling Inositol 1,4,5-trisphosphate receptors
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IP3 signaling
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Stable transfectant Jurkat T cells do not express IP3R1 IP3R1
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Activation of IP3-gated Ca 2+ channel by fyn
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Bcl-2 P Bcl-2 Bcl-2 Bcl-2 Rec Growth Factor Plasma Membrane Cytoplasm PIP2 PLC- IP3 ER Bad P Degradation 14-3-3 Bcl-x Bad Ca 2+ IP3R Calcineurin SERCA Ca 2+ Cytosolic TF Nuclear TF Survival Nucleus Cell Death DNA Digestion M M Akt Cytoskeletal Breakdown Cytochrome C Caspases CAD Bad Survival + X ? Calcium signaling during apoptosis Calcium signaling during apoptosis
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VGCC Stretch receptor CNG nAChR IP3R RyR VDAC SERCA NCE PMCA mM [Ca] 100 nM [Ca] mM [Ca] T-tubule Sarcoplasmic reticulum Endoplasmic reticulum mitochondria
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