1. Ferran Sanz – GRIB Research Programme on Biomedical Informatics (GRIB)

2. Ferran Sanz – GRIB What is the GRIB? GRIB is a research programme of both Universitat Pompeu Fabra (UPF) and IMIM. IMIM is the research institute ofHospital del Mar (PSM)and it is academically affiliated to the UPF. GRIB is located in the Biomedical Research Park of Barcelona (PRBB). GRIB is also the Biomedical Informatics node of the Spanish Institute of Bioinformatics (INB).

3. TICs and computational approaches are mandatory tools for managing and exploiting the immense amounts of data that are currently generated in the biomedical research (experimental, clinical, epidemiological). Mission: To invent, develop and apply computational methods that, through an intensive use of and information technologies, allow a better understanding and prediction of biological phenomena, giving especial emphasis to those related to the human diseases and their treatment. GRIB Mission

4. Ferran Sanz – GRIB GRIB themes and organisation GRIB is organised in six thematicin silico labs: Computational Genomics: Computational analysis of genomic sequences and information. PIs: M. Albà, E. Eyras, N. Lopez-Bigas & R. Castelo. Structural Bioinformatics:Analysis and modelling of protein structures and interactions. PI: B. Oliva. Computational Biochemistry and Biophysics:Modelling and simulation of biophysical and biochemical phenomena at molecular and systemic scales. IPs: J. Villà-Freixa and G. de Fabritiis. Chemogenomics: Computational annotation and analysis of massive molecular DBs vs. protein families showing therapeutic interest. IP: J. Mestres. Computer-Assisted Drug Design:Molecular modelling and multivariate statistical analysis in the drug R&D. IPs: M. Pastor, J. Selent & I. Zamora (part time) Integrative Biomedical Informatics:Integrative knowledge management in biomedical research. IP: F. Sanz. +Management office.Manager: C. Donlo

5. Ferran Sanz – GRIB The GRIB team The GRIB staff is a multidisciplinary team of +70 professionals (+20PhDs), which includes: biologists, pharmacists, chemists, physicians, computer scientists, mathematicians research management staff

6. Ferran Sanz – GRIB GRIB research outcomes * Without including Complex System Lab. publications

7. Ferran Sanz – GRIB GRIB research outcomes Average IF of the journals of GIB publications (2005-09): 5.33 No. of citations of papers published in 2005-07: 1668

8. Ferran Sanz – GRIB GRIB develops open source and proprietary software that is internationally recognised. GRIB research has generated two spin-off: Pharmatools Chemotargets GRIB research outcomes

9. Integrative knowledge management in pharmacovigilance Literature mining in silicosimulation Pathway analysis Genetic polymorphisms 30M EHRs from 4 EU countries ! www.alert-project.org

10. Possible drug – AE relationship to be assessed Biological pathways Genetic variants (SNPs) Drug Adverse event Similar drugs-ligands Drug metabolites Involved proteins Workflows for chemo- & bio-informatics signal substantiation

11. Ferran Sanz – GRIB GRIB’s strategic priority The GRIB aims to enhance its biomedical focus, putting the emphasis in the clinical application of the bioinformatics and knowledge management approaches that it develops. In particular, we are currently developing a strategic collaboration with Hospital del Mar (PSM)on the research exploitation of its clinical information system (IMASIS).

12. Ferran Sanz – GRIB grib.imim.es