1. Biology 107 Macromolecules I September 5, 2003

3. Macromolecules I Student Objectives:As a result of this lecture and the assigned reading, you should understand the following: 1.The four major types of organic macromolecules are: carbohydrates, lipids, proteins, and nucleic acids. 2.Carbohydrates generally have molecular formulas that are some multiple of CH 2 O, and carbohydrates range from single small sugar molecules (monosaccharides) to long polymers of sugar monomers (polysaccharides). a.Structure - Monosaccharides have two or more -OH groups and either an aldehyde or a ketone group. Polysaccharides may be straight or branched molecules of hundreds or thousands of sugar monomers. Some sugars are highly negatively charged because they are commonly sulfated (SO 3- ) or because they contain a carboxyl group (COO - ).

4. Macromolecules I b.Functions - energy source, recognition or signaling, and/or structural. 3.Lipids consist mainly of C and H atoms linked by nonpolar covalent bonds; consequently, lipids are not attracted to polar water molecules, and lipids are hydrophobic. a.Structure – Fats and oils are large lipids made from glycerol and fatty acids. Triglyceride fats consist of three (3) fatty acid chains hooked to a glycerol molecule. For saturated fats, every C atom of the carbon skeleton (except the carboxyl carbon) carries 2 H atoms (the maximum number of hydrogens). In contrast, unsaturated fats contain double bonds and less than the maximum number of hydrogens possible.

5. Macromolecules I Phospholipids, the major components of cellular membranes, are structurally similar to fats except they contain a phosphate group and only 2 fatty acid chains attached to the glycerol. Steroids are lipids with the carbon chain bent to form fused rings. Cholesterol is a common substance in animal cell membranes. Animal cells also use cholesterol as a precursor for making other steroids, including male and female sex hormones. b. Functions - energy storage, membrane structure, hormone signaling, and/or insulation.

6. Four Main Types of Macromolecules

7. Common Carbohydrates Classified by Number of Carbons

8. Examples of Hexose Isomers

9. Examples of Linear Compared to Ring Forms of Carbohydrate

10. Disaccharides

12. Polysaccharides Examples:StarchCellulose

13. Lipids - Fats

14. Triglyceride Fats

15. Saturated Fatty Acid Chains

16. Unsaturated Fatty Acid Chains

17. Phospholipids

19. Phospholipids in Water

20. Structure of Phospholipids and Steroids

21. Examples of Lipids Other Than Phospholipids or Steroids