1. Miki Lee / OEB 192 – 08.11.12 Mobile genetic elements and adaptive mutation

2. IS family http://www-is.biotoul.fr/

3. Effects on bacterial evolution An important source of genetic variation – Insertion – Homologous recombination

5. Effects on bacterial evolution

7. — M-evolved — S-evolved — M+S-evolved — M/S-evolved

9. 1 2 3 4

10. Mutation Luria–Delbrück experimentCairns–Foster system

11. Modified Cairns–Foster system

13. Kugelberg E. et.al. PNAS 2006;103:17319-17324

15. Monday (11/17): Physiological basis of fitness

16. Upcoming talks Tuesday, 12/16 Rich Lenski Michigan State University 12:30 pm, 341 Warren Alpert (HMS)