1. Bimonthly Meeting on September 12, 2008 Uncertainty in Transcription of Lesion Contours to Diffusion Weighted Magnetic Resonance Images Amarjeet Bhullar

2. Motivation: Calculate ADC Non-Diffusion Weighted ImageDiffusion Weighted Image Contour by Clinician lesion

3. Method: Geometric Algorithm

5. Signal Intensity on a DWMRI Measured Signal Signal W/O Diffusion Gradients Diffusion Coefficient b Factor 42 MHz/Tesla (proton gyromagnetic ratio) Strength of the diffusion gradient pulses Duration of the diffusion gradient pulses Time between diffusion gradient RF pulses

6. Least Squares Fitting Intercept: Slope: SD:

7. Calculation: ADC for Patient # 004

8. Calculation: ADC for Patient # 005

9. Calculation: ADC for Patient # 002

10. Calculation: ADC for Patient # 001

11. Points : How to handle Uncertainty in ADC values. Suggestions are welcome