1. Biodefense-related Research UMDNJ-New Jersey Medical School Nancy Connell, Ph.D. Director, UMDNJ Center for Biodefense Vice-chair for Research Department of Medicine

2. UH-EMS Center for Biodefense 9-11 DoDfunding2000DoDfunding2001 DoDfunding2002,2003 Emerging Pathogens 1999 MOU With NYC Newark: MMRS WMD first- Responder training Incident Support And Operational Planning (2002) HHS funding (NJDoHSS) 2002, 2003 Mobilization of expertise Anthraxattacks MOU NJDoH “Public Health War College” Member:Domestic Preparedness Task Force - NJ BT annex Univ. Hospital plan: State model Renew MOU With NYC HRSA Funding 2003 NIH- Regional Center of Excellence in Biodefense Regional Biocontainment Laboratory ICPH (PHRI) INFORM

3. Biological Agent Research Capacity in Newark Center for Emerging and Re-emerging Pathogens (NJMS) International Center for Public Health –NJMS Microbiology –NJMS Nat’l TB Center –Public Health Research Inst

4. Biological agents Bacillus anthracis Yersinia pestis Burkholderia mallei Francisella tularensis Mycobacterium tuberculosis Hantaan virus Dengue virus Monkeypox Influenza virus SARS

5. Biological research areas Diagnostics –DNA microarrays –Molecular beacons Host response –Testing vaccine response (smallpox vaccine) –Infection models –Antibiotic resistance

6. DNA microarrays Infection by different organisms will turn on and off different patterns of genes in the host. Can we determine these patterns and use them for early diagnosis of infection?

7. DNA microarray analysis of the host response to infection NJMS/NJDS: Gallagher Alland Raveche Schutzer CBD: Jessica Mann Paula Trzop Carolina Sofer CAG (PHRI) Pat Soteropoulos Anthony Galante NJIT Michael Recce Virginie Airis avirulent vs virulent 37 uninfected vs virulent 80 uninfected vs virulent Total genes 44,561 61 18 0 3 0

8. NIH Regional Center of Excellence in Biodefense and Emerging Pathogens Northeast Biodefense CenterNortheast Biodefense Center (among 8 of 14 applied) Consortium of 30 institutions: NY, NJ, CT 200 + investigators (P.I., Ian Lipkin [Columbia]) Commissioner Lacy: advisory board 3 New Jersey investigators on executive committee $45 million total award (5 yrs): $ 2 million to PHRI’s David Perlin as animal core director Vaccines, therapeutics, diagnostics, training Strong emphasis on global emerging infections (SARS, West Nile)

9. NIH Regional Biocontainment Laboratory Joint effort of NJMS and PHRI $21 million award with 1/3 match by UMDNJ 40,000 sq ft building adjacent to ICPH University Heights Science Park Jeannette Brummel, community liason Brings total Newark BSL space to 22,000 sq ft

10. NIH biodefense research priorities CAG (PHRI) Keck Center (Rutgers) Beacons (NJMS, PHRI) Arrays (NJMS) The RBL: NJMS, PHRI PHRI Northeast Biodefense Center