1. Ch18 Pattern Formation – Regeneration Types of Regeneration: 1.Stem Cells (undifferentiated) 2.Morphallaxis 3.Epimorphosis 4.Compensatory Regeneration (differentiated)

2. Pattern Formation Regeneration Epimorphosis

3. Regeneration Epimorphosis Limb regeneration - Blastema What is necessary for limb regeneration? Denerve then amputated  ? Amputation  add NGF  ? Nerve transplants in animals which normally lack regeneration: Newborn Opposum 1. Hindlimb Amputation  ? 2.Supplemental nerve tissue  ?

4. Epimorphosis

5. Hydra freshwater cnidarian Morphallaxis

7. Hydra – regeneration gradients Head Activator vs. Head Inhibitor both from Hypostome Budding - level of HA at gastric bud Role of nerves

9. Compensatory Regeneration