1. Chem 509 Signal Transduction Winter 2010 Lecture 2

3. What difference between Gs, Gq and Gi?: 1.Gs, G protein that is stimulatory and binds AC 2.Gq, G protein that is stimulatory and binds PLC 3.Gi, G protein that is inhibitory and binds AC.

5. Phosphatidylinositol Phosphatidylinositol- diphosphate

6. Phospholipases Phospholipase A1-can hydrolyse the sn-1 acyl bond but can also hydrolyse the sn-2 acyl bond. In the former case, this liberates a fatty acid and 2-acyl-glycerophospholipid.

7. Phospholipases Phospholipase A­2-hydrolyses the sn-2 acyl bond. This liberates a fatty acid and a lysophospholipid (1-acyl-glycerophospholipid)

8. Phospholipases Phospholipase C-hydrolizes one phosphoester bond to generate diacyglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).

9. Phospholipases Phospholipase D-will hydrolyse the other phosphoester bond to generate phosphatidic acid (amphiphilic product) and inositol 4,5 diphosphate (IP2).

10. PI=Phosphatidylinositol, Phosphorylated derivatives of PI are denoted as PIPx. PC=Phosphatidylcholine PA=Phosphatidic acid Lyso PC= deacylated phosphatidylcholine

12. Calmodulin

15. End of GPCR lecture story

16. Insulin signaling

18. Other Receptor Tyrosine Kinase Receptors

19. Cross talk (part of integration of signals)

20. Brief overview of cancer signaling pathways

21. Cell cycle