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Effects of NGF
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Developmental processes during which apoptosis can occur
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Glial survival depends on growth factor from axon
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Apoptosis vs. Necrosis
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Apoptotic cell
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DNA Fragmentation
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Sources of trophic signals
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Effects of targets and afferents
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Signal-activation of caspase
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Bax Activation PI3 Kinase NOT activated Akt NOT activated Cytosolic BAX migrates to mito. Cytochrome C release Caspase 9 Caspase 3
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BDNF Trk B Y-P SHC RAS PI3 kinase Akt Blocks BAX migration To the mitochondria. No Cytochrome C release No Caspase activation Bax Inhibition
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