1. Work of Breathing Components 1. Compliance work65% (stretching lungs & chest wall) 2. Airways resistance work30% 3. Moving tissues  5% Normally <1–3% Total Energy (E)  in exercise, still <3–5% total E output

2. Compliance =  Volume  Pressure

3. Lung resists stretching: 1.Tissue expansion: Small component normally Fig. shows lung expansion involves an unfolding of elastin and collagen fibers in the alveolar walls. The actual lengths of the individual fibers change little.

4. dynes / cm Major component : surface tension

5. Lung surfactant protein-phospholipid from alveolar type 2 cells Functions 1.  surface tension of fluid in alveoli, so lungs able to expand with normal muscle activity. 2. Stabilizes alveoli from collapse surface tension is lowered more in small alveoli than in larger alveoli P = 2T r

6. Small alveolus Large alveolus surfactant molecules more concentrated surfactant molecules more diluted Fig. shows surface tension alters alveoli stability. The smaller alveoli generate a greater pressure and cause air to flow into larger units. Surfactant promotes alveolar stability by lowering surface tension proportionately more in the small alveoli.

8. Compliance work  1. where  surfactant ~ premature babies (smoking) 2. where lung tissue fibrotic (scar tissues) ~ coal miners ~ asbestosis 3. where chest wall expansion limited ~ scoliosis ~ tight bandages 4. at high lung volumes

9. Fig. shows static expiratory pressure  volume curves of lungs in normal subjects and subjects with pulmonary fibrosis.  compliance work

10. Airway Resistance Airway resistance is increased by  turbulent flow e.g. rapid breathing airway narrowing Gas flow = pressure gradient resistance with laminar flow resistance  1 radius 4

11. Small peripheral airways each has small diameter but many of them so total cross-sectional area is high reactive smooth muscle in wall

12. Fig. shows schematic representation of airway branching in the human lung with approximate dimensions.

13. Causes of airway narrowing in expiration vs inspiration ~ expiratory forces tend to push airways shut worse if little support for airways ~ emphysema = lung tissue destruction floppy airways close during expiration air trapping smooth muscle constriction e.g. asthma inflammation, mucus, mucosal swelling e.g. chronic bronchitis asthma

14. Airway resistance is affected by: 1. Structure of lungs ~ resistance is higher in upper airways (trachea/bronchi etc) ~ lower in small airways (large total cross- sectional area, laminar flow) 2. Mechanical factors: Airway resistance is  in expiration vs inspiration expiratory forces tend to push airways shut worse if little support for airways ~ airway resistance is lower at high lung volumes – airways held open ~ airway resistance is lower during inspiration vs expiration

15. 3. Smooth muscle tone in small airways ~ sympathetic input  relaxation ~ parasympathetic input  constriction ~ immune response e.g. asthma  allergen/cold  triggers immune response  inflammatory mediators released  smooth muscle constriction, mucosal swelling and mucus secretion 4. Local reflexes: Areas with  PCO 2 cause bronchiolar smooth muscle contraction: important for ventilation- perfusion matching

16. Mechanical factors cont: ~ airway resistance may be high during expiration due to dynamic airways collapse during expiration (forced expiration, “floppy” airways in emphysema) Emphysema = lung tissue destruction  floppy airways  close during expiration  air trapping

17. Spirometry Forced expiratory volume in 1 sec F E V 1 ~ measure of airways obstruction and/or dynamic airway compression ~ since F E V 1 also affected by F V C (forced vital capacity) F E V 1 / F V Cratio used N ratio  80%

18. FEV 1 = 3.2L FVC = 4L FEV 1 = 1.5L FVC = 3.2L

19. Peak flow

20. Overall Work of Breathing 1. Compliance work is greatest at high lung volumes 2. Airways resistance work is greatest at rapid airflow rates ie highest respiratory rate / min V T = V T x resp rate L / min minute ventilation tidal vol

21. Work of breathing (summary) Compliance work. ~ surfactant measurement: static compliance curve spirometry ~ airways resistance work measurement: alternative: peak flow meter F E V 1 F V C  V  P