1. Chapter 12 (part 1)
Citric Acid Cycle

2. Electron Transport and Oxidative phosphorylation
Gylcolysis
Electron Transport and
Oxidative phosphorylation
TCA Cycle

4. Entry into the TCA Cycle

5. Pyruvate Dehydrogenase

7. Citrate Synthase
Only step in TCA cycle that involves the formation of a C-C bond

9. Aconitase

11. Isocitrate Dehydrogenase

13.  -Ketoglutarate Dehydrogenase

15. Succinyl-CoA Synthetase

18. Fumarase

20. Malate Dehydrogenase

22. Reduced Coenzymes Fuel ATP Production
Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20  HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+
Isocitrate Dehydrogenase 1 NADH=2.5 ATP
a-ketoglutarate dehydrogenase 1 NADH=2.5 ATP
Succinyl-CoA synthetase GTP=1 ATP
Sunccinate dehydrogenase 1 QH2=1.5 ATP
Malate Dehydrogenase 1 NADH=2.5 ATP
Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA

24. Regulation of TCA Cycle

26. Protein/amino acid
Catabolites feed
Into the TCA Cycle

27. Fats breakdown and feed
into the TCA Cycle

28. TCA Cycle provides intermediates for many biosynthetic processes

29. The Anaplerotic Reactions
The "filling up" reactions
PEP carboxylase - converts PEP to oxaloacetate
Pyruvate carboxylase - converts pyruvate to oxaloacetate
Malic enzyme converts pyruvate into malate

30. Following the carbons through the TCA cycle