1. Aneurysm Model Prototype: Design Update Sara Goldgraben Bill Hauser Michael Savarese Advisor: Dr. Strey Customer: Dr. Chen BME 441 Design April 3, 2006

2. Overview Background Original Design Pre-manufacturing Modifications Initial Prototype Testing Post-Manufacturing Modifications Additional Models Near Future Experiments Lab Setup

3. Background Required parameters Aneurysm neck: 4mm Aneurysm neck: 4mm Vasculature diameter: 4mm Vasculature diameter: 4mm Aneurysm diameter: 7mm Aneurysm diameter: 7mm Flow Velocity: 100cm/min Flow Velocity: 100cm/min Transparent Housing Optical data acquisition Optical data acquisition Mechanically strong Mechanically strong Easily Disassembled Maintenance Maintenance Weight measurement of polymer Weight measurement of polymer Durable Durable Water-tight seals Seal of aneurysm and input/output flow Seal of aneurysm and input/output flow Versatility of Design Reusability Reusability Variable flow Variable flowVelocitySteady/Pulsatile

4. Original CAD Design Size of materials Plexiglas Plexiglas O-rings O-rings

5. Pre-Manufacturing Modifications Consultation with George Luhrs Sizes are in closest American standard to our metric requirements Overall Model Stems From 2D Model Idea Double Plug Double Plug Single Plug Single Plug Added Handle with grip O-ring Sealed Plug High Tolerance Machined Plug New Design Size: 5in x 2in Size: 5in x 2in Straight Fluid Flow Straight Fluid Flow Mostly Seamless Mostly Seamless Solid Machined Fittings Solid Machined Fittings Improvements Over Original Design Smaller Overall Dimensions Smaller Overall Dimensions Eliminates long entry length Eliminates long entry length Less Material Used Less Material Used Less Chance of Leaks Less Chance of Leaks Solid Machined Fittings Solid Machined Fittings

7. Initial Prototype Testing Prototype: High Tolerance Fitting Results Positive PositiveWater-tight Machined Barbed Fittings Work Well Negative Negative Aneurysm Cracks Opaque Tint Requires Further Polishing Requires Further Polishing

8. Post-Manufacturing Modifications Enlarged Plug Larger Aneurysm Wall Larger Aneurysm Wall Will reduce aneurysm weakness Reduction of Opacity Polishing PolishingMechanical Cloth Tip Cloth Tip Wooden Tip (Plausibility not yet known) Wooden Tip (Plausibility not yet known) Polishing Solution Heat Based Baking Baking Heated Ball Bearings Heated Ball Bearings

9. Additional Models Lateral Wall Aneurysm Models 11mm and 13mm Aneurysm 11mm and 13mm Aneurysm 4mm vessel 4mm vessel Bifurcated Aneurysm 10-11mm Aneurysm 10-11mm Aneurysm 4mm vessel 4mm vessel

10. Near Future Experiments Test Polishing Methods Test Model with Polymer Easily Cleaned Easily Cleaned Sufficiently Transparent Sufficiently Transparent No Optical Artifacts No Optical Artifacts

11. Lab Setup Assembly Safety Precautions Barometer set up Experimental setups Static flow (reservoir is gravity driven) Static flow (reservoir is gravity driven) Dynamic flow (pump) Dynamic flow (pump) Closed loop Open loop

12. Conclusion Budget Breakdown Pump = $400 Pump = $400 Plexiglas = $80 Plexiglas = $80 Large O-Rings (Not being used) = $35 Large O-Rings (Not being used) = $35 Stand/Clamps/etc = $120 Stand/Clamps/etc = $120 Total so far = $635 Total so far = $635

13. Acknowledgements Professor Chen – Customer Professor Strey – Advisor George Luhrs – machined our product Lester Orlick – Instructional Support Technician CEAS Greg Pollard – APT Instruments