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Author(s): Gerald Abrams, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution–Non-commercial–Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact open.michigan@umich.edu with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
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Citation Key for more information see: http://open.umich.edu/wiki/CitationPolicy Use + Share + Adapt Make Your Own Assessment Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation License Creative Commons – Zero Waiver Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (USC 17 § 102(b)) *laws in your jurisdiction may differ Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Government: Works that are produced by the U.S. Government. (USC 17 §105) Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis to determine whether or not your use will be Fair. { Content the copyright holder, author, or law permits you to use, share and adapt. } { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } { Content Open.Michigan has used under a Fair Use determination. }
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M1 Patients and Populations: DISTURBANCES OF GROWTH NEOPLASIA I Gerald D. Abrams MD Fall 2008
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ORGANS/TISSUES SMALLER THAN NORMAL DEVELOPMENTAL AGENESIS APLASIA HYPOPLASIA ATRESIA ACQUIRED ATROPHY
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UNILATERAL RENAL AGENESIS Department of Pathology, University of Michigan
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UNILATERAL RENAL HYPOPLASIA Department of Pathology, University of Michigan
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LIVER, “BROWN ATROPHY” G.D. Abrams, University of Michigan Medical School
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ORGANS / TISSUES LARGER THAN NORMAL HYPERTROPHY INCREASE IN CELL SIZE HYPERPLASIA INCREASE IN CELL NUMBER
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HEART, NORMAL Department of Pathology, University of Michigan
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HEART, HYPERTROPHY Department of Pathology, University of Michigan
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MYOCARDIUM, NORMAL G.D. Abrams, University of Michigan Medical School
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MYOCARDIUM, HYPERTROPHY G.D. Abrams, University of Michigan Medical School
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SKIN, NORMAL G.D. Abrams, University of Michigan Medical School
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SKIN, HYPERPLASIA G.D. Abrams, University of Michigan Medical School
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SKIN, HYPERKERATOSIS G.D. Abrams, University of Michigan Medical School
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MAMMARY GLAND G.D. Abrams, University of Michigan Medical School
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MAMMARY GLAND, LACTATING G.D. Abrams, University of Michigan Medical School
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PROSTATE, HYPERPLASIA Source Undetermined
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BREAST- FIBROCYSTIC CHANGE Source Undetermined
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NORMAL BREAST G.D. Abrams, University of Michigan Medical School
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BREAST FIBROCYSTIC CHANGE G.D. Abrams, University of Michigan Medical School
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ABNORMAL PATTERNS OF CELL GROWTH / DIFFERENTIATION METAPLASIA DYSPLASIA
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ENDOCERVIX, SQUAMOUS METAPLASIA G.D. Abrams, University of Michigan Medical School
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ENDOCERVIX, SQUAMOUS METAPLASIA G.D. Abrams, University of Michigan Medical School
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SQUAMOUS EPITHELIUM, NORMAL G.D. Abrams, University of Michigan Medical School
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SQUAMOUS EPITHELIUM, MODERATE DYSPLASIA G.D. Abrams, University of Michigan Medical School
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SQUAMOUS EPITHELIUM, SEVERE DYSPLASIA G.D. Abrams, University of Michigan Medical School
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NEOPLASM / “TUMOR” MASS (“NEW GROWTH”) – PROLIFERATING CELLS AUTONOMOUS NON-EQUILIBRIUM, UNCOORDINATED GROWTH PERSISTENT / IRREVERSIBLE
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NEOPLASTIC TRANSFORMATION SERIES OF GENETIC EVENTS CLONAL CHARACTERISTICS
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Benign Tumor: growth by expansion Malignant Tumor: growth by invasion Regents of The University of Michigan
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BENIGN AND MALIGNANT GROWTH BENIGN COHESIVE /EXPANSILE CIRCUMSCRIBED / LOCALIZED MALIGNANT POORLY CIRCUMSCRIBED / INVASIVE….METASTASIZING
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UTERUS, LEIOMYOMA Department of Pathology, University of Michigan
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UTERUS, LEIOMYOMA G.D. Abrams, University of Michigan Medical School
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BREAST CANCER Department of Pathology, University of Michigan
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COLON CANCER Department of Pathology, University of Michigan
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COLON CANCER Department of Pathology, University of Michigan
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CANCER INVADING COLONIC WALL G.D. Abrams, University of Michigan Medical School
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METASTASIS A COMPLEX CASCADE OF EVENTS VIA BLOOD VIA LYMPH DIRECT
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CANCER CELLS WITHIN BLOOD VESSEL G.D. Abrams, University of Michigan Medical School
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CANCER CELLS WITHIN LYMPHATIC G.D. Abrams, University of Michigan Medical School
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PERITONEUM, CARCINOMATOSIS Department of Pathology, University of Michigan
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PERITONEAL METASTASES Department of Pathology, University of Michigan
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LIVER, METASTASES Department of Pathology, University of Michigan
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EYE, PRIMARY MALIGNANT MELANOMA Department of Pathology, University of Michigan
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LUNG, METASTASES Department of Pathology, University of Michigan
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VERTEBRAE, METASTASES Department of Pathology, University of Michigan
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VERTEBRA, METASTASIS Department of Pathology, University of Michigan
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BRAIN, METASTASIS Department of Pathology, University of Michigan
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LIVER, METASTASES Department of Pathology, University of Michigan
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Slide 5: Department of Pathology, University of Michigan Slide 6: Department of Pathology, University of Michigan Slide 7: G.D. Abrams, University of Michigan Medical School Slide 9: Department of Pathology, University of Michigan Slide 10: Department of Pathology, University of Michigan Slide 11: G.D. Abrams, University of Michigan Medical School Slide 12: G.D. Abrams, University of Michigan Medical School Slide 13: G.D. Abrams, University of Michigan Medical School Slide 14: G.D. Abrams, University of Michigan Medical School Slide 15: G.D. Abrams, University of Michigan Medical School Slide 16: G.D. Abrams, University of Michigan Medical School Slide 17: G.D. Abrams, University of Michigan Medical School Slide 18: Source Undetermined Slide 19: Source Undetermined Slide 20: G.D. Abrams, University of Michigan Medical School Slide 21: G.D. Abrams, University of Michigan Medical School Slide 23: G.D. Abrams, University of Michigan Medical School Slide 24: G.D. Abrams, University of Michigan Medical School Slide 25: G.D. Abrams, University of Michigan Medical School Slide 26: G.D. Abrams, University of Michigan Medical School Slide 27: G.D. Abrams, University of Michigan Medical School Slide 30: Regents of the University of Michigan Slide 32: Department of Pathology, University of Michigan Slide 33: G.D. Abrams, University of Michigan Medical School Slide 34: Department of Pathology, University of Michigan Slide 35: Department of Pathology, University of Michigan Slide 36: Department of Pathology, University of Michigan Slide 37: G.D. Abrams, University of Michigan Medical School Slide 39: G.D. Abrams, University of Michigan Medical School Slide 40: G.D. Abrams, University of Michigan Medical School Slide 41: Department of Pathology, University of Michigan Slide 42: Department of Pathology, University of Michigan Slide 43: Department of Pathology, University of Michigan Slide 44: Department of Pathology, University of Michigan Slide 45: Department of Pathology, University of Michigan Slide 46: Department of Pathology, University of Michigan Slide 47: Department of Pathology, University of Michigan Slide 48: Department of Pathology, University of Michigan Slide 49: Department of Pathology, University of Michigan Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicy
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