1. Introduction of Micro-mixer

2. Lab on a chip

3. Mixing principles

4. Micro-scale Micro-scale => laminar flow conditions
=> difficult to mix

5. Modes of Mixing Passive Active Split and recombine Serial segmentation
Rotation
Chaotic vortex
Supply external energy
Thermal
Acoustic
Electro-somotic
Mechanical
Passive
Active

6. Mixing by diffusion

7. Diffusive micro mixer - and gradient generator
Whitesides G. et al, Langmuir, Vol. 16, No. 22, 2000,

8. Laminated flow cell scanner
Orwar O. et al Anal. Chem. 2002, 74,

9. Laminated flow cell scanner - and decade gradient generator
Orwar O. Et al Anal. Chem. 2005, 77,

10. Distributive micromixing chip

12. Chaotic advection micro mixers - 3D rotation of the laminated flows
Nuguyen N-T., Fundamentals and applications of microfluidics

13. Chaotic advection serpentine mixer -3D rotation of the laminated flows -
BEEBE D. et al. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, VOL. 9, NO. 2, JUNE 2000

14. Chaotic advection in serpentine mixer

15. Chaotic advection mixing -grooved channel bottom-
G.M. Whitesides et al SCIENCE VOL JANUARY

16. Chaotic advection mixing -patterned channel bottom-
Nuguyen N-T., Fundamentals and applications of microfluidics

17. Chaotic advection mixing - periodic herring bone pattern -
G.M. Whitesides et al SCIENCE VOL JANUARY

18. Chaotic advection mixing -periodic herring bone pattern-

19. Dispersion properties of herringbone mixer
Straight
Herringbone
G.M. Whitesides et al Science Vol Jan

20. Serially segmented chaotic mixer
P. Tableing et al Physical Review E 72, , 2005

21. Multilamination mixing
Jensen K F. et al, Ind. Eng. Chem. Res., Vol. 44, No. 8, 2005

22. Multilamination mixing and alkaline hydrolysis of methyl formate

23. Multiphase mixing

24. Semented flow mixing - gas/fluid -
Jensen KF. et al Langmuir, Vol. 21, No. 4, 2005

26. Re-Pe diagram Pe - inertia (advection) in relation to diffusion
Re - inertia (advection) in relation to viscous
effects(laminar)

27. Hydrodynamic Focusing
On the order of
30 nm in the
extreme cases
TO MIX IN TENS OF MICROSECONDS
Austin et al, PRL (2002)

28. Circular micromixing

29. Circular mixer
Circular
micromixer
Quake, Scherer (2001)

30. In chaotic regimes, two close particles separate exponentially
In confined systems, this property is extremely favorable to mixing,

31. From Ottino’s book : « Chaotic Advection »

32. Thermal mixer Thermal actuator Micromixer
J. Evans, D. Liepmann, D., and A.P. Pisano, 1997, “Planar Laminar Mixer,” Proceeding of the IEEE 10th Annual Workshop of Micro Electro Mechanical Systems (MEMS ’97), Nagoya, Japan, Jan, pp

33. Advection mixer V Time periodic transverse flow time -V Fluid A Fluid
Main Flow
Time periodic transverse flow
time -V
Fluid B
400 mm
investigated by Y.K. Lee, C.M.Ho (1999), Mezic et al (1999)

34. U U
Perturbation
is applied
Line is stretched U
Perturbation
is stopped
Line is folded

35. Micro-valve 25mm 200mm Microvalve 1mm actuation channel Glass slide
Working channel
1mm

37. Actuation
pressure
(bar)
Frequency (Hz)

38. RESONANCES MAY BE USED TO SORT PARTICLES : An efficient
particle sorter, using resonance
RESONANCES
MAY BE USED TO SORT
PARTICLES :
BY CHANGING THE FREQUENCY OF THE PERTURBATION, ONE
OBTAINS A SYSTEM WHICH MIXES FLUIDS, FILTERS PARTICLES,
OR SIMPLY TRANSPORTS MATERIALS SIDE BY SIDE.

39. A.Dodge, P. Tabeling, A. Hountoundji, M.C.Jullien (2004)