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The InterAct Project Dr Claudia Langenberg, MRC Epidemiology Unit, Cambridge 14th of February 2011, Institute of Public Health.

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Presentation on theme: "The InterAct Project Dr Claudia Langenberg, MRC Epidemiology Unit, Cambridge 14th of February 2011, Institute of Public Health."— Presentation transcript:

1 The InterAct Project Dr Claudia Langenberg, MRC Epidemiology Unit, Cambridge 14th of February 2011, Institute of Public Health

2 The InterAct Project An Examination of the Interaction of Genetic and Lifestyle Factors on the Incidence of Type 2 Diabetes Objectives To discover how genetic and lifestyle behavioral factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. EPIC nested case-cohort study To investigate how these discoveries may help to prevent the development of diabetes. Lifestyle intervention studies

3 InterAct Research Lines RL1 Analysis of gene-lifestyle interaction in observational studies of diabetes incidence RL2 Analysis of nutritional factors and physical activity in observational studies of diabetes incidence RL3 Analysis of genetic factors in observational studies of diabetes incidence RL4 Analysis of gene-lifestyle interaction in intervention studies

4 InterAct Participants European, nested case-cohort study of 12,403 cases of incident type 2 diabetes and a subcohort of 15,376 participants conducted in 26 (21) centres in 8 European countries. Ascertainment and exclusion of all prevalent cases. Ascertainment and verification of T2D cases. Selection on a random subcohort (proportionate to T2D incidence and oversampled for prevalence).

5 InterAct Cases & Subcohort EPIC Europe: 5.42 million person-years (n=455,680) InterAct Denominator: 3.99 million person-years (340,234) Random subcohort: 16,835 Exclusions: 681 Prevalent diabetes (548), post- censoring diabetes (4), unknown status (129) Exclusions: No stored buffy coat/ blood (109,625) or no diabetes status reported (5,821) Ascertained T2D cases: 17,928 (17,407 from ascertainment, 521 identified in verification) Random subcohort (post exclusions): 16,154 Verified incident T2D cases: 12,403 Exclusions: 5,525 Denmark (2,577), not diabetic (838), prevalent diabetes (421), post-censoring diabetes (101), unknown status (1,588) Overlap: 778 verified incident T2D cases

6 HRs for T2D per 1 SD difference in waist and BMI

7 Cumulative risk of T2D in the subcohort by sex, BMI and waist groups

8 Main effects iPLEX1 (n=21,178; 9,233 cases/ 11,945 random controls)

9 www.inter-act.eu

10 Acknowledgements

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