1. HEART AND ITS NEIGHBORHOOD NEURAL CREST CELLS migrate from hindbrain region via pharyngeal arches to conotruncal region of heart.

2. BLOOD VESSELS OF THE EMBRYO (at 26 days)

3. AORTIC ARCHES SCHEMATIC 1 2 3 6 4 5 7 iseg Ventral aorta Dorsal aorta

4. AORTIC ARCHES SCHEMATIC 3 6 4 1 2 5 7 iseg Ventral aorta Dorsal aorta

5. 6 3 3 4 4 7 iseg AORTIC ARCHES AND DERIVATIVES Aortic sac Truncus arteriosus 6

6. 6 3 3 4 4 7 iseg AORTIC ARCHES AND DERIVATIVES

7. 6 3 3 4 4 7 iseg AORTIC ARCHES AND DERIVATIVES

8. LCC RCC RSC BCA LSC DA AORTIC ARCHES AND DERIVATIVES

9. 6 3 3 4 4 7 iseg RECURRENT LARYNGEAL NERVES

10. LCC RCC RSC BCA LSC DA RECURRENT LARYNGEAL NERVES

11. 3 6 4 1 2 5 7 iseg Ventral aorta Dorsal aorta DOUBLE AORTIC ARCH

12. DOUBLE AORTIC ARCH: “Vascular ring” Causes airway obstruction, stridor in infancy.

13. 3 6 4 1 2 5 7 iseg Ventral aorta Dorsal aorta RIGHT AORTIC ARCH

14. RIGHT AORTIC ARCH: Mirror image branching

15. 3 6 4 1 2 5 7 iseg Ventral aorta Dorsal aorta ABERRANT RIGHT SUBCLAVIAN ARTERY

16. LCC RCC RSC LSC DA ABERRANT RIGHT SUBCLAVIAN ARTERY

17. Occurs in 0.5% of people. Frequently asymptomatic, it may cause obstructive symptoms.

18. COARCTATION OF THE AORTA Notching of ribs on X-ray Blood pressure difference Upper extr >>Lower extr. Associated with: 45X: Turner’s synrome Trisomy 21: Down’s syndrome 70% have bicuspid aortic valve >90% post (juxta) ductal

19. ABDOMINAL ARTERIES

20. Umbilical Vitelline VENOUS SYSTEM SCHEMATIC Sinus Venosus Cardinal

21. © 2005 Elsevier UMBILICAL AND VITELLINE VEINS- I: Liver, portal vein and ductus venosus.

22. UMBILICAL AND VITELLINE VEINS- II: Liver, portal vein and ductus venosus.

23. Cardinal Subcardinal Supra cardinal Supra-Subcardinal Anastomosis Umbilical Vitelline VENOUS SYSTEM SCHEMATIC Sinus Venosus C P A

24. THE CARDINAL VEINS AND THE VENAE CAVAE

26. SINUS VENOSUS AND THE CORONARY SINUS

27. VENOUS (SMOOTH WALLED) PART OF ATRIA

28. PERSISTENT LEFT SVC 0.3% of general population. 4 % of patients with Cong. Ht Dis. Usually drains to Coronary sinus. Usually asymptomatic. Enlarged coronary sinus is a clue.

29. LYMPHATIC SYSTEM

30. FETAL CIRCULATION

31. POSTNATAL CIRCULATION

32. PATENT DUCTUS ARTERIOSUS Prostaglandins: Keep the ductus Patent Indomethacin: Closes the ductus. Physiologic closure: Normally 82% by 48hrs, 100% by 4 days. Anatomic closure: 12 weeks. Patent Ductus :-prematurity. -neonatal hypoxic states. -maternal Rubella infection

33. CELL LINEAGES IN HEART DEVELOPMENT FHF = First Heart Field; SHF = Second Heart Field; CNC: Cardiac Neural Crest Ref: Srivastava, D. Making or Breaking the Heart: From Lineage Determination to Morphogenesis.Cell 126, Sep. 22, 2006 p1037-1048.

34. MOLECULAR PATHWAYS IN HEART DEVELOPMENT Ref: Srivastava, D. Making or Breaking the Heart: From Lineage Determination to Morphogenesis.Cell 126, Sep. 22, 2006 p1037-1048.

35. Genetic Mutation Syndrome Name Cardiac Disease Nonsyndromic NKX2-5— Atrial septal defect, ventricular septal defect, electrical conduction defect GATA4—Atrial septal defect, ventricular septal defect MYH6—Atrial septal defect NOTCH1—Aortic valve disease Syndromic TBX5Holt-Oram Atrial septal defect, ventricular septal defect, electrical conduction defect TBX1DiGeorgeCardiac outflow tract defect TFAP2βCharPatent ductus arteriosus JAG1AlagillePulmonary artery stenosis, tetralogy of Fallot PTPN11NoonanPulmonary valve stenosis ElastinWilliamSupravalvar aortic stenosis FibrillinMarfanAortic aneurysm Genetic Mutations in Congenital Heart Disease Ref: Srivastava, D. Making or Breaking the Heart: From Lineage Determination to Morphogenesis.Cell 126, Sep. 22, 2006 p1037-1048.

36. MOVIE!