1. Slide 1 September 14, 2010 Pierce Hall McLean Hospital Research Town Meeting

2. Slide 2 1.General Announcements 2.Announcement: New Division 3. Portfolio Management 4. Grant Administration Competencies 5. Q&A / Open Forum 6. Cataldo Mentoring Award Presentation 7. Reception McLean Research: Town Meeting Agenda

3. Slide 3 1.Effort Reporting 2.InSight - New Fund Balance Statements 3.Faculty / Post-doc Review Templates 4.McLean Research Intranet Added Feature: “Feedback / How Can We Help?” 5. McLean Research Day Thursday, January 13 th, 2011, 1:00 - 5:30 p.m. McLean Research: General Announcements

4. Slide 4 Division of Basic Neuroscience Chief: Joseph T. Coyle, MD (Effective October 1, 2010) New Division

5. New Federal Grants since January 1, 2010 S. Andersen: R01 Early drug exposure and drug reward mechanisms D. Balu: F32 Molecular Mechanisms of Dendritic Abnormalities Related to D-Serine Deficiency V. Bolshakov: R01 Synaptic mechanisms in extinction of conditioned fear V. Bolshakov: R03 Functional role of vesicular zinc in synaptic mechanisms in the amygdale E. Chartoff: R01 Role of dopamine signaling in the mood-related effects of salvinorin A M. Copersino: K23 Multimodal Brain Imaging of Functional Neurodyynamics in Cocaine Dependence B. Frederick: S10 4 Tesla MR Spectroscopy Console Upgrade Slide 5

6. New Federal Grants since January 1, 2010 Slide 6 B. Frederick: R21 Real time near infrared spectroscopy of the frontal lobe for Neurofeedback M. Hall: K01 Functional Characterization of Risk Variants for Psychotic Illness in the GWA Er E. Jensen: R21 Proton Echo-Planar Spectroscopic Imaging of GABA, Glutamate/Glutamine at 4 Tesla R. Karmacharya: K08 Wnt/GSK3/ beta-Catenin Singaling as a Target for Treatment of Bipolar Disorder K. Kim: R01 Protein-induced human iPS cells for personalized cell therapy for PD N. Mello: R01 Sex/gender and nicotine addiction: hormones, behavior and neuroimaging K. Myers: K01 NMDA receptor-mediated plasticity in extinction of conditioned opiate withdrawal

7. New Federal Grants since January 1, 2010 G. Noam: NSF Empirical- Development of an Observation Tool for the Informal Science Field U. Rudolph: R21 Generation of etiological models for schizophrenia by chromosome engineering M. Silveri: R01 Neurobiological consequences of binge alcohol consumption in young adults M. Silveri: R21 Sex Differences and Alcohol Dependence: Hippocampal Neurochemistry and Function M. Teicher: R01 Sensitive Periods, Brain Development and Depression M. Thomsen: K99 Elective muscarinic receptor ligands as targets for cocaine addiction medication Slide 7

8. Slide 8 Research Portfolio Management McLean Research

9. Slide 9 McLean Research: Portfolio Management In order to enhance research portfolio management and to reduce research fund deficits:  Enhance financial reports, tools and oversight processes for improved fund management and more accurate and timely identification of fund in deficit and at imminent risk of deficit  Update, communicate and ensure compliance with policies and procedures  Improve communication between Research Administration and McLean research community  Expand support of researchers

10. Slide 10 McLean Research: Portfolio Management  Enhance financial reports, tools and oversight processes for improved portfolio and fund management and more accurate and timely identification of fund in deficit and at imminent risk of deficit 1.Reports for McLean PIs, Research Administration and Finance a)Insight financial reports b)InfoEd – Proposal Tracking; Proposal Development 2.Re-mapping of Chief of Service codes 3.Processes a)Resource projections annually by lab b)Regularly recurring tracking of fund balances and burn rates by Research Administration and Finance  Early warning to PIs as needed

11. Research Fund Management Initiative  Update, communicate and ensure compliance with policies and procedures 1.Review, clarify and update policies and procedures a)Simplify when possible 2.Develop manual that includes: a)Detailed responsibilities of PI, lab-based research administrators and Research Administration b)Checklists for PIs and grant managers c)Procedure flow charts d)Organizational chart 3.Provide contacts who can offer support and guidance 4.Make information more easily accessible a)Research Intranet (research.mclean.harvard.edu) Slide 11

12. Research Fund Management Initiative  Improve communication between Research Administration and McLean research community Optimize use of modes of communication 1.Research Intranet 2.Email 3.Departmental Research Administrators Workgroup (DRAW) 4.Research Committee 5.Mailman Research Center Steering Committee 6.Research Town Meeting Slide 12

13. Research Fund Management Initiative  Expand support of researchers 1.Continue Research Admin open door policy for PIs and administrators in addition to regular office hours for:  Pre-award  Time and effort reporting  Post-award  Research Finance  Portfolio management 2.Enhance training a)New PIs b)Lab-based research administrators c)General research community Slide 13

14. Slide 14 Grant Oversight Grant Administration Competencies McLean Research

15. Slide 15 McLean Research Goal: Ensure that all PI’s and research grant administrators at McLean Hospital have requisite knowledge and skills to manage their grants.  Advisory Committees:  DA’s (DA’s and PI’s)  PI’s (PI’s)  Training  Assessment and feedback

16. Slide 16 McLean Research Changing Research Landscape:  Increasing complexity of federal regulations  Public demand for research accountability / transparency  Significant audits / settlements  Greater scrutiny  Effort reporting  Cost Allocation  Cost transfers  Unallowable costs  Subrecipient monitoring  Delinquent reporting to sponsor

17. Slide 17 McLean Research Principal Investigators:  Roles and Responsibilities  Scientific Integrity  Effort and Salary  Financial Oversight  Conflict of Interest http://phsresearchintranet.partners.org/PHS_ResearchMgmt/PHSResearchCompliance-PIQuickGuide.asp

18. Slide 18 McLean Research Department Administrators:  Roles and Responsibilities  Pre-Award, Progress Report Documents  Subcontracts  Allowable Costs  Income & Expense  Effort Reporting http://phsresearchintranet.partners.org/PHS_ResearchMgmt/PHSResearchCompliance-DAQuickGuide.asp

19. Slide 19 McLean Research Questions Open Forum

20. Slide 20 McLean Research Presentation 2010 Anne M. Cataldo Excellence in Mentoring Award to Ross J. Baldessarini, MD