1. OXIDATIVE STRESS

2. INDUCTION OF OXIDATIVE STRESS Glutathione conjugation MalnutritionMutation Phagocytic activation Tissue damageSmoking

3. OXIDATIVE STRESS AND DISEASES Aging Cancers Degenerative disorders: Alzheimer’s disease & Parkinson’s disease Cardiovascular diseases: Atherosclerosis

4. OXIDATIVE STRESS AND AGING

5. OXIDATIVE STRESS AND CANCERS Free radicals Oxidation of DNA Free radicals Inhibition of antioxidant defense mechanism

6. OXIDATIVE STRESS AND PARKINSON’S DISEASE Increased hydrogen peroxide formation increases dopamine oxidation. Decreased glutathione level in substantia nigra. Formation of hydroxy radical by increased iron concentration in substantia nigra. Increased lipid peroxidation in substantia nigra.

7. OXIDATIVE STRESS AND ALZHEIMER’S DISEASE Normal Aging, Mutations Elevation of  -amyloid  -amyloid polymerization Production of ROS Lipid peroxidation Tau protein formation Neuronal dysfunction

8. OXIDATIVE STRESS AND ATHEROSCLEROSIS

9. THERAPEUTIC ANTIOXIDANTS