1. Figure 7.1 The Biology of Cancer (© Garland Science 2007) What’s dominant? Cell Fusion Allows Interaction Of Disparate Genomes

2. Retinoblastoma strikes in childhood and is easily diagnosed. RETINOBLASTOMA

3. Figure 7.5a The Biology of Cancer (© Garland Science 2007)

4. Figure 7.5b The Biology of Cancer (© Garland Science 2007) Familial vs sporadic Retinoblastoma Retinoblastoma Pedigree

5. Figure 7.8 The Biology of Cancer (© Garland Science 2007) Heterozygosity – 2 ways of Losing it Mitotic Recombination Gene Conversion

6. Figure 7.13 The Biology of Cancer (© Garland Science 2007) Testing For Loss of Heterozygosity By Southern Blot By PCR

7. Figure 7.14 The Biology of Cancer (© Garland Science 2007)

8. Figure 7.16 The Biology of Cancer (© Garland Science 2007) Losing Heterozygosity – A Third Way Methylation An example

9. Figure 7.19 The Biology of Cancer (© Garland Science 2007) Many Tumor Suppressors are Silenced by Hypermethylation

10. Figure 7.21 The Biology of Cancer (© Garland Science 2007) NF-1 – Neurofibromatotosis -1 is a GTPase Activating Protein

11. Figure 7.24a The Biology of Cancer (© Garland Science 2007) APC -/- APC +/- or +/+ APC, β-Catenin & Intestinal Crypts

12. Figure 7.25a The Biology of Cancer (© Garland Science 2007)

13. Figure 7.28a The Biology of Cancer (© Garland Science 2007) The Von Hippel Landau tumor Suppressor and HIF-1

14. Figure 7.29b The Biology of Cancer (© Garland Science 2007)