1. 1 Dynamic Contrast Enhanced T 2 * Perfusion MR Imaging Presented by: Meng Li

2. 2 Introduction  Fundamental Principle A bolus of contrast agent goes through a capillary network Transient changes in the MR signal MR signal time course concentration-time course (of tracer in tissue) tissue hemodynamic parameters (i.e., CBF,CBV,MTT)

3. 3 Introduction Fig.1 DSC-MRI in a 4 year old child 12 hours after a stroke in the left basal and signal intensity time course plots ROI 1: right basal ganglia, ROI 2: left basal ganglia, ROI 3: peripheral branch of the right MCA Stroke region (ROI 2) shows almost no contrast agent passage. ROI 1 ROI 2 ROI 3

4. 4 Introduction  Quantification of Bolus Tracking Using Summary Parameters BAT: bolus arrival time TTP: time to peak MPC: maximum peak concentration AUP: area under the peak FWHM: full width at half maximum