1. Synthetic Skin

2. Guide Lines Introduction Introduction Definition Synthetic Skin Definition Synthetic Skin Industry State Industry State Synthetic Skin Manufacturing process Synthetic Skin Manufacturing process Synthetic Bone Manufacturing process Synthetic Bone Manufacturing process Conclusion Conclusion

3. Introduction Many burned people die, their body couldn ’ t produce new skin Many burned people die, their body couldn ’ t produce new skin Skin is important to protect body from infection and harmful bacteria Skin is important to protect body from infection and harmful bacteria Skin is largest organs in the body Skin is largest organs in the body Skin keep vital fluid in Skin keep vital fluid in

4. Introduction Traditional solution replacing the skin with another human or animal skin Traditional solution replacing the skin with another human or animal skin Some of the body rejects others skin Some of the body rejects others skin So, alternative solution needed So, alternative solution needed Synthetic Skin is invented by Burke and Yannas Synthetic Skin is invented by Burke and Yannas

5. Definition Synthetic Skin is laboratory production for substitution of human skin (tissue Engineering) is laboratory production for substitution of human skin (tissue Engineering) Tissue Engineering is Knowledge of building or repairing human organ Tissue Engineering is Knowledge of building or repairing human organ Cells brought from lab or patients blood used to initiate the process Cells brought from lab or patients blood used to initiate the process

6. Industry State Tissue Engineering has made great progress in the Science Tissue Engineering has made great progress in the Science However, It seemed to be less successful in business However, It seemed to be less successful in business Two companies leading industry has went through a bankruptcy Two companies leading industry has went through a bankruptcy Though the need is high the margin profit is low relative to the high cost of the manufacturing Though the need is high the margin profit is low relative to the high cost of the manufacturing Manufactures couldn ’ t sustain its self Manufactures couldn ’ t sustain its self

7. Industry State Another reason of the failure is that the manufactures lack of automated processes Another reason of the failure is that the manufactures lack of automated processes Sales of Skin Engineered is about half the US,50 million output of the tissue Engineering Sales of Skin Engineered is about half the US,50 million output of the tissue Engineering The rest comes from the Engineered joints replacements The rest comes from the Engineered joints replacements To transform the Skin Engineered process into automated processes high precise sensores are needed which added to the coast To transform the Skin Engineered process into automated processes high precise sensores are needed which added to the coast

8. Synthetic Skin Manufacturing process Skin, composed of two layers called epidermal (the outer layer) and dermal (the inner layer) Skin, composed of two layers called epidermal (the outer layer) and dermal (the inner layer) Outer layer protect the body from bacteria and infections Outer layer protect the body from bacteria and infections Inner layer contains the blood vessels, nerves and hair Inner layer contains the blood vessels, nerves and hair

9. Synthetic Skin Manufacturing process Dish fill of liquid of nutrient that helps in skin growth Dish fill of liquid of nutrient that helps in skin growth Process starts as donated foreskin cells Process starts as donated foreskin cells Foreskin cells: epidermal and dremal Foreskin cells: epidermal and dremal

10. Synthetic Skin Manufacturing process

13. Using only labor manual process only 50,000 skins produces in a year Using only labor manual process only 50,000 skins produces in a year So Automated processes needed So Automated processes needed Machine that refresh nutrient liquid every day (increase the time of growth) Machine that refresh nutrient liquid every day (increase the time of growth) Temperature monitor, steady environment increase the growth Temperature monitor, steady environment increase the growth

14. Synthetic Bone Manufacturing process Unlike skin,3D tissue design and growth is required Unlike skin,3D tissue design and growth is required atoumatic X-ray and resonance imaging atoumatic X-ray and resonance imaging Data taken Data taken This data is digitized into computer aided design (CAD) This data is digitized into computer aided design (CAD) Then dimensions of slices are computed Then dimensions of slices are computed

15. Synthetic Bone Manufacturing process

17. What do you expect from Tissue Engineering In future? What do you expect from Tissue Engineering In future? Many challenges slowing down the development Many challenges slowing down the development Challenging Automation production, finding good resources of cells and preserving the organs after its construction Challenging Automation production, finding good resources of cells and preserving the organs after its construction Conclusion