1. The PATCHED (Ptc) Gene Brendan McQuellon

2. What is PATCH Transmembrane surface receptor Binds ligands of Hedgehog(Hh) family Weinberg, 2007

3. Normal Ptc Role Controls cell fate by inhibiting Hh/Shh signaling Inhibits the transcription of Hh/Shh target genes Can regulate the cell cycle

4. Shh/Ptc/Gli pathway Weinberg, 2007 http://www.armchairempire.com/i mages/feature-articles/Weekly- Top-10/pub-crawl/sonic- hedgehog.jpg

5. Shh/Ptc/Gli pathway Weinberg, 2007 http://www.armchairempire.com/images/fe ature-articles/Weekly-Top-10/pub- crawl/sonic-hedgehog.jpg

6. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

7. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

8. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

9. Sonic hedgehog and Patched regulate neural development Goodrich et al, 2007 www.pressthebuttons.com/

10. How KO’s were made Goodrich et al., 1997

11. Heterozygous Mice Goodrich et at., 1997

12. Heterozygous Mice Goodrich et at., 1997

13. How does Ptc relate to cancer? Gorlin Syndrome –Basal Cell Carcinomas –Medulloblastomas Sporadic Instances Ionizing Radiation http://www.medicalecology.org/images/atmosphere/skincancer1.gif

14. How does Ptc relate to cancer? Meningiomas, Breast and Esophageal carcinomas Shh/Ptc pathway hyperactive in many other cancers