1. Characterization of delivery systems for nanomedicine Dr. John A. Dagata

2. source: NCI CNPlan Benefits and advantages of nanomedicine: Targeted nanoparticle delivery systems One of the most promising nanomedicine platforms Use an engineered virus-like particle to direct therapeutics & diagnostics only to cancer cells Lower dosage Reduced costs & side effects

3. NIST-NCI-FDA Alliance: Impact of healthcare costs on the US economy Protocols and standards for faster move into clinical trials CNPlan (NCI 2004) Critical Path Initiative (FDA 2004) Technology: Methodologies for nonspecific adhesion of bio-nanoparticles to surfaces for high-magnification imaging and characterization

4. Commercial Applications: Drug discovery and development Quality assurance (manufacturability and potency) Environmental health & safety

5. Drug discovery and development (collaboration with Esther Chang, Georgetown University Medical Center)

6. 500 nm Metrology of soft material: Small sample volume (10  L) Adjustment of solution properties (essential for actual drug formulations) Fluid scanning probe microscopy of intact liposomes Non-optical statistical size distribution and zeta potential SPM tip SPIO NDS tip probing liposome tip probing SPIO

7. Collaboration Opportunities: CRADA SBIR For technical details see the posters: Physical characterization of liposome-based targeted nanoparticle delivery systems with encapsulated MRI contrast agents Imaging, characterization, and manipulation of nanobioparticles: Fluid scanning probe and surface zeta potential measurements of targeted delivery systems N. Farkas, et al.

8. Contact Information: John A. Dagata Precision Engineering Division Manufacturing Engineering Laboratory National Institute of Standards & Technology 100 Bureau Drive MS 8212 Gaithersburg MD 20899-8212 301-975-3597 tel. 301-869-0822 fax john.dagata@nist.gov