1. Figure 48.1 Overview of a vertebrate nervous system

2. Neuron

3. Conduction of the Nerve Impulse Membrane Potential –Voltage measured across a membrane due to differences in electrical charge –Inside of cell is negative wrt outside Resting potential of neuron = -70 mV

4. Figure 48.6 Measuring membrane potentials

6. 1. Carrier in membrane binds intracellular sodium. 2. ATP phosphorylates protein with bound sodium. 3. Phosphorylation causes conformational change in protein, reducing its affinity for Na +. The Na + then diffuses out. 4. This conformation has higher affinity for K +. Extracellular K + binds to exposed sites. 5. Binding of potassium causes dephosphorylation of protein. Extracellular Intracellular ATP ADP PiPi P + K+K+ Na + 6. Dephosphorylation of protein triggers change to original conformation, with low affinity for K +. K + diffuses into the cell, and the cycle repeats. PiPi PiPi PiPi Sodium-Potassium Pump

7. Excitable Cells Neurons & muscle cells Have gated ion channels that allow cell to change its membrane potential in response to stimuli

9. Gated Ion Channels Some stimuli open K+ channels –K+ leaves cell –Membrane potential more negative –hyperpolarization Some stimuli open Na+ channels –Na+ enters cell –Membrane potential less negative –depolarization

10. Gated Ion Channels Strength of stimuli determines how many ion channels open = graded response

11. Nerve Impulse Transmission

12. Action Potentials Occur once a threshold of depolarization is reached –-50 to –55 mV All or none response (not graded) –Magnitude of action potential is independent of strength of depolarizing stimuli Hyperpolarization makes them less likely

13. Membrane potential (mV) 2. Rising Phase Stimulus causes above threshold voltage +50 0 12 3 –70 Time (ms) 1. Resting Phase Equilibrium between diffusion of K + out of cell and voltage pulling K + into cell Voltage-gated potassium channel Potassium channel Voltage-gated sodium channel Potassium channel gate closes Sodium channel activation gate closes. Inactivation gate opens. Sodium channel activation gate opens 3. Top curve Maximum voltage reached Potassium gate opens 4. Falling Phase Potassium gate open Undershoot occurs as excess potassium diffuses out before potassium channel closes Equilibrium restored Na + channel inactivation gate closes K+K+ Na + Na + channel inactivation gate closed

14. Refractory Period During undershoot the membrane is less likely to depolarize Keeps the action potential moving in one direction

15. Propagation of Action Potential Action potential are very localized events DO NOT travel down membrane Are generated anew in a sequence along the neuron

16. Cell membrane Cytoplasm resting repolarized depolarized + + + + + + + + + – – – – – – – – – + + + + + + + + + – – – – – – – – – – – + + + + + + + + + – – – – – – – + + + + + + + – – – – – – – – – + + + + – – + + + + + – – + + – – – – – + + + + + – – + + – – – – – + + – – + + + + – – – + + – – – – + + + – – + + – – – + + + + – – + + + – – – – + + + + + + + – – – – – – – – – + + – – + + + + + + + + + – – – – – – – Na + K+K+ K+K+ K+K+ K+K+ K+K+ K+K+

17. Supporting Cells - Neuroglia provide neurons with nutrients, remove wastes Two important types in vertebrates –Oligodendrocytes – myelin sheath in CNS –Schwann cells -myelin sheath in PNS

18. Myelin Sheath Formation

20. Saltatory Conduction

21. Transfer of Nerve Impulse to Next Cell Synapse –the gap between the synaptic terminals of an axon and a target cell

22. Transfer of Nerve Impulse to Next Cell Electrical synapses –Gap junctions allow ion currents to continue Chemical synapses –More common –Electrical impulses must be changed to a chemical signal that crosses the synapse

23. Chemical Synapses