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Cell Division and Apoptosis II chapter 17. Activation of a cyclin dependent kinase.

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Presentation on theme: "Cell Division and Apoptosis II chapter 17. Activation of a cyclin dependent kinase."— Presentation transcript:

1 Cell Division and Apoptosis II chapter 17

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5 Activation of a cyclin dependent kinase

6 CdK activity can be suppressed by inhibitory phosphorylation

7 CdK activity can be suppressed by inhibitory proteins

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9 Cell fusion experiments

10 Assembly of pre-replicative complex during G1 phase

11 Entry into mitosis is blocked by incomplete DNA replication Hydroxyurea blocks DNA synthesis Caffeine causes failure of checkpoint

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16 The Rb protein acts as a brake in mammalian cells

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19 Overview of cell cycle control system

20 Programmed Cell Death - Apoptosis

21 Digits in developing mouse paw are formed through apoptosis cells undergoing apoptosis

22 Apoptosis causes tadpole to lose tail

23 Necrosis vs. apoptosis

24 DVD clip 77

25 Procaspase is activated by an active caspase

26 Caspase cascade occurs during apoptosis

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29 An animal cell depends on extracellular signals to survive or divide

30 An animal cell depends on extracellular signals to differentiate. Without extracellular signals the cell will die

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34 Platelet derived growth factor was the first mitogen isolated stimulates cell division during wound healing

35 Mitogens stimulate G1-Cdk and G1/S-Cdk activities


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