1. Key Researchers, University of Aarhus, Denmark Thomas Sangild Sørensen – Research Assistant Professor – Master of Science in Computer Science (MSCS) – PhD in Medicine Jesper Mosegaard – Lecturer, Institute of Information Studies – Master of Science in Computer Science (MSCS) – PhD candidate in Computer Science (thesis defence November 2006) Karsten Østergaard Noe – Master of Science in Computer Science (MSCS) – PhD fellow in Computer Science

2. Key clinical partners Aarhus University Hospital, Denmark – Dept. Cardiothoracic Surgery, Vibeke Hjortdal, Professor of Surgery, MD – Dept. Cardiology, Senior Consultant, Keld Sørensen, MD – Dept. Oncology, Cai Grau, Research Professor, MD Guys Hospital, Kings College, London – Reza Razavi, Professor of Cardiovascular Imaging, MD University Hospital Tubingen, Germany – Ludger Sieverding, Professor of Cardiology, MD Clinic of Congenital Heart Disease, Ruhr University Bochum, Germany – Philipp Beerbaum, Director of Pediatric Cardiac MRI, MD

3. Surgical Simulation on the GPU Real-time simulation of surgical procedures on congenitally malformed hearts Can we reduce mortality rates in complex surgery? Scenarios – Training of novice surgeons – Preoperative surgical planning of patient-specific procedures [ Click for Movie ]

4. Reconstruction Morphological models reconstructed from 3D MRI – Patient-specific morphology – Possibly enhanced by post- processing if used for educational purposes – On the model to the right we image a patient with several atrial and ventricular septal defects – i.e. holes between the main chambers of the heart

5. Technical requirements Real-time tissue deformation – The CPU is simply not fast enough – Use the GPU for general computations instead >20-fold acceleration The GPU can significantly accelerate computations in a range of medical simulation applications

6. Dose planning in radiotherapy CT imaging of neck cancer The tumor (arrow) shrinks during treatment It will be advantageous to update the dose plan according to the morphological changes A deformable registration method (accelerated >30 times on the GPU) is used to calculated the accumulated dose