1. IBD Ulcerative Colitis Crohn’s Disease

2. IBD  Pathogenesis – genetics +environment (smoking,infection,drugs)  UC –bloody diarrhoea. Exacerbation & remission-50%/yr  CD- more heterogenous – abdo pain,diarrhoea,wt loss,malaise,fever. 80% require surgery

3. Diagnosis  Colonoscopy – unless presenting with severe disease.  Terminal ileoscopy + BaFT  CT/MR/US/WBC scanning

4. Management  5ASAs + steroids – local/systemic  Azathioprine- good. TPMT assay  UC – consider CyA/infliximab  CD – Mtx/infliximab  The future – newer biological therapies