1. Circulatory Responses

2. Purpose transport oxygen to tissues transport of nutrients to tissues removal of wastes regulation of body temperature

3. Organization arteries - away from heart (oxygenated) veins - to heart (deoxygenated) arterioles - branches capillaries - smallest arteries venules - smallest veins mixed venous blood - from entire body

4. Structure of the Heart

5. The Heart has Two Pumps pulmonary - pumps blood to the lungs and back to the left side of the heart from the lungs systemic - pumps blood to the rest of the body and back to the right side of the heart

6. The Myocardium

7. Cardiac Cycle Systole –contraction phase –0.3 sec at rest down to 0.2 sec during heavy exercise Diastole –relaxation phase –0.5 sec at rest down to 0.13 sec during heavy exercise

8. The Cardiac Cycle Systole –Contraction phase Diastole –Relaxation phase

9. Pressure Changes During the Cardiac Cycle

10. Insert fig 9.4 two heart sounds –1st closing of the atrioventricular valves –2nd closing of the aortic and pulmonary valves

11. Blood Pressure arterial blood pressure estimated using sphygmomanometer –systolic/diastolic –males 120/80 –females 110/70 Hypertension –resting BP of 140/90 –primary or secondary

12. Blood Pressure Determination Pulse pressure –difference between systolic and diastolic Mean arterial pressure (MAP) –product of cardiac output and total vascular resistance (sig?) –average pressure during cardiac cycle –determines rate of blood flow through system –MAP = DBP +.33 (pulse pressure)

13. Factors Affecting Blood Pressure Blood pressure can be increase by –increase in blood volume –increase in heart rate –increase in blood viscosity –increase in stroke volume –increased peripheral resistance

14. Anterior View of the Heart

15. Normal electrocardiogram at rest

16. Use of ECG for Diagnosis (ST depression)

17. Cardiac Output Q = HR x SV –Q = cardiac output –HR = heart rate –SV = stroke volume Implications during exercise???

18. Insert table 9.1

19. Regulation of Heart Rate Parasympathetic control –cardiovascular control center (medulla oblongota) –vagus nerve –acetylcholine decreases activity of both SA and AV nodes –can increase HR by removal

20. HR Regulation cont’d Sympathetic control –cardiac accelerator nerves at SA and AV nodes –norepinephrine released which increases HR and force of contraction –responsible above 100 bpm

21. Autonomic Control of HR

22. Regulation of Stroke Volume end diastolic volume (EDV) - volume of blood in ventricles at the end of diastole –Frank-Starling Law –increase in contractility increases volume pumped per beat –venous return average aortic blood pressure strength of ventricular contraction

23. Factors Regulating Venous Return venoconstriction –reduces volume capacity of veins to store blood –sympathetic control muscle pump respiratory pump –inspiration reduces intrathoracic pressure

24. The Skeletal Muscle Pump

25. Components of Blood Plasma –Liquid portion of blood –Contains ions, proteins, hormones Cells –Red blood cells Contain hemoglobin to carry oxygen –White blood cells –Platelets Important in blood clotting Hematocrit –Percent of blood composed of cells

26. Hematocrit