1. Genotyping Results Each person was typed for 3 unlinked Short Tandem Repeat loci (STR) vWFII – chromosome 12, intron 40 of the vWF gene UT 2203 – chromosome 4, 60.16 cM UT 1376 – chromosome 4, 132.05 cM Individual genotyping results are in the MED2011_FALL_Genotypes.pdf file Allele frequencies for this class are compared to previous medical school classes and to other world populations using a neighbor-joining tree based on genetic distance estimates

2. Example – 3 STR markers UT1376 288, 288 UT2203 199, 202 vWFII 154, 162 A size marker (orange) is used to establish allele sizes STR Genotype 150-180 bp Size ranges for all alleles 185-205 bp 277-305 bp vWFIIUT2203UT1376

3. Allele frequencies vWFIIUT2203UT1376 allele (bp) frequency

4. Genotype Summary and Sharing 83 Participants, 3 STRs vWFIICounts 154,1627 154,1664 154,1742 158,1625 158,1664 158,1701 162,1629 162,16619 162,1701 162,1742 162,1782 164,1681 166,1668 166,1702 166,1743 170,1741 174,1743 No call9 UT2203Counts 199,19924 199,20239 202,2029 No call11 UT1376Counts 281,2892 285,2851 285,28910 285,2932 285,2971 289,28925 289,29316 289,2971 291,2911 293,2932 293,2971 No call21 3 Loci CombinedCounts 162,166199,199289,2894 158,162199,202289,2893 162,166199,202281,2892 162,162199,202289,2892 162,162199,199289,2892 No Call25 Unique45

5. Population Tree