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DA dendrite formation
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Dendrite guidance
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Clock model: axonal and dendritic growth are internally regulated, depending on how to respond to guidance molecules
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WT Robo3 over- expression in TTMn Robo3 over- expression in both GF & TTMn GF, giant fiber interneuron TTMn: tergotrochantral motor neuron
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Neuropil model: same guidance molecules for attracting (or including) axon and dendrite together for synapse TRENDS in Neurosciences Vol.27 No.4 April 2004
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achaete scute atonal amos Proneural genes Sensory organs + associated MD neurons solo-MD neurons
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ESMD / mono-ESMD / poly-ES CHMD / CH solo-MD ASC ato amos Brewster and Bodmer, 1995 ES CH MD amos
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Control of dendrite development Luo. et al. Trends Neuroscience (2003)
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DA Dendrite formation
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Constitutive active CDC42 induce supernumerary primary dendrites that fail to extend dorsally and grow secondary dendrites WT CDC42 pros mutations causes routing defect
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Lateral branch defects: (A) WT, (B) reduced, (C) fail to extend, (E, F) over shrinking Increased density
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Sequotia ( 水杉 ), Zn finger protein
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No repulsion in dorsal group No invasion into ablated region in dorsal region in third instar
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Competition between two dorsal groups of contralateral dorsal groups
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Dorsal dendrite overextension in flamingo mutants
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Class I Class II
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Class III
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Development (2002) Grueber et al Tiling of dendrites within the same class of DA neurons
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Cell (2003) Grueber et al
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Dendrites of different classes overlap extensively Class III and IVClass I and IV
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Class IV tiling
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Differential Cut levels in four types of DA neurons
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cut mutant phenotypes in class III
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Class II Class I
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Class II
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Class IV No effect on class III
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Dendrites over-branching and over-lapping phenotypes
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Defect in like-dendrite avoidance response WT fry
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Heteroneuronal tiling defect Trc kinase Rac Fry branching tiling
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