1. 1 Protocol Update LAE 6/6/08

2. 2 3/23/07 – First patient enrolled Glioblastoma Multiforme (GBM) - scanned. Second scan on 5/8/07. Subsequent biopsy of disease site. Subsequently, he withdrew. 4/15/08 – Fifteenth patient enrolled. 5/27/08 – Most recent scan. Thirteenth patient scanned second time. New, more coarse, MRS voxel grid. Protocol Enrollment 2

3. 3

4. 4 Magnetic Resonance Spectroscopy Initial Voxel grid likely too fine  Low signal to noise and poor data quality. Tom Chong constructed nice summary of his work in this area. See I:\Physics\MRS_DWMRI_Protocol\MRSbackup (E)