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DNA Repair
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Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS CANCER
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Source of Damage Endogenous: Replication Errors Reactive Oxygen Species Exogenous: UV radiation, IR.. Mutagenic chemicals
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Type of Damage- Endogenous Oxidation of bases Methylation of bases Hydrolysis of bases Mismatch of bases Damage mostly on DNA bases, causing point mutations:
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Type of Damage- Exogenous UV light- pyrimidine dimers IR- Breaks in DNA strands Chemicals (found in smoke, soot and tar)- diversity of DNA damages including crosslinking of DNA. Damage mostly on helix structure:
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DNA MutationDNA Damage ≠
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The cellular DNA damage response Transducers Mediators Sensors Effectors Cell cycle arrest DNA repairApoptosisDNA repair DNA damage
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DNA Repair Mechanisms
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DNA Mismatch repair
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Base Excision Repair
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Nucleotide excision repair
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Nucleotide Excision Repair in Eukaryotes
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Xeroderma Pigmentosum
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